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Table 13 Changes of D-dimer from baseline negative/indeterminate to >1000 μgm/dl after 28 ± 2 days

From: Low dose compared to variable dose Warfarin and to Fondaparinux as prophylaxis for thromboembolism after elective hip or knee replacement surgery; a randomized, prospective study

  Changed from 0 – 999 at baseline to >1,000 after 28 ± 2 days
Yes No p-value for hip vs. knee
n (%) n (%)  
Hips 45 (31.5 %) 98 (68.5 %) <0.0001
Knees 116 (70.7 %) 48 (29.3 %)  
Patients with elevated D-dimer (>1,000 μg/dL) at follow-up, stratified for knee vs. hip and study arm
  Arm A Arm B Arm C A vs. B A vs. C B vs. C
p-value p-value p-value
Knees 12 of 47 (25.5 %) 15 of 50 (30.0 %) 18 of 46 (39.1 %) 0.624 0.163 0.348
Hips 41 of 54 (75.9 %) 38 of 59 (64.4 %) 37 of 51 (72.5 %) 0.185 0.693 0.362
Total 53 of 101 (52.5 %) 53 of 109 (48.6 %) 55 of 97 (56.7 %) 0.577 0.551 0.247