Low dose compared to variable dose Warfarin and to Fondaparinux as prophylaxis for thromboembolism after elective hip or knee replacement surgery; a randomized, prospective study

Table 13 Changes of D-dimer from baseline negative/indeterminate to >1000 μgm/dl after 28 ± 2 days

	Changed from 0 – 999 at baseline to >1,000 after 28 ± 2 days
	Yes	No	p-value for hip vs. knee
	n (%)	n (%)
Hips	45 (31.5 %)	98 (68.5 %)	<0.0001
Knees	116 (70.7 %)	48 (29.3 %)
Patients with elevated D-dimer (>1,000 μg/dL) at follow-up, stratified for knee vs. hip and study arm
	Arm A	Arm B	Arm C	A vs. B	A vs. C	B vs. C
	Arm A	Arm B	Arm C	p-value	p-value	p-value
Knees	12 of 47 (25.5 %)	15 of 50 (30.0 %)	18 of 46 (39.1 %)	0.624	0.163	0.348
Hips	41 of 54 (75.9 %)	38 of 59 (64.4 %)	37 of 51 (72.5 %)	0.185	0.693	0.362
Total	53 of 101 (52.5 %)	53 of 109 (48.6 %)	55 of 97 (56.7 %)	0.577	0.551	0.247

ISSN: 1477-9560