Table 2 Exclusion criteria

1. Abnormal platelet count, prothrombin time (PT) or partial thromboplastin time (PTT)

2. Surgery for acute fracture (<4 weeks), septic joint, or extraction arthroplasty

3. History of VTE or documented hypercoagulation syndrome

4. Increased risk of hemorrhage, as from active gastric ulcer or urinary tract bleed within the last year

5. Hemorrhagic stroke; brain, spinal, or ophthalmologic surgery in previous 6 months

6. Liver enzymes or bilirubin greater than 2 x normal

7. Decreased renal function with GFR <30 ml/min.

8. Cancer in last year, other than localized cancers of the skin

9. Requires chronic anticoagulation

10. Requires chronic platelet function suppressive therapy

11. Prior adverse reaction to any of the study drugs

12. Uncontrolled hypertension

13. BMI >42

14. Pregnancy