Low dose compared to variable dose Warfarin and to Fondaparinux as prophylaxis for thromboembolism after elective hip or knee replacement surgery; a randomized, prospective study

Bern, Murray M.; Hazel, Diane; Deeran, Elizabeth; Richmond, John R.; Ward, Daniel M.; Spitz, Damon J.; Mattingly, David A.; Bono, James V.; Berezin, Ronna H.; Hou, Laura; Miley, Gerald B.; Bierbaum, Benjamin E.

doi:10.1186/s12959-015-0062-0

Table 5 Baseline laboratory results

From: Low dose compared to variable dose Warfarin and to Fondaparinux as prophylaxis for thromboembolism after elective hip or knee replacement surgery; a randomized, prospective study

Laboratory tests		ARM A	ARM B	ARM C	A vs B	A vs C	B vs C
Laboratory tests		ARM A	ARM B	ARM C	p value	p value	p value
Routine laboratory units (± 1 Standard Deviation)
Hips	Hemoglobin	13.9 (1.2)	14.0 (1.4)	13.7 (1.5)	0.921	0.765	0.525
	Platelets (x 1,000)	245.3 (51.8)	244.2 (53.8)	252.3 (47.0)	0.993	0.753	0.685
	BUN	17.2 (5.0)	17.5 (4.8)	18.0 (7.3)	0.963	0.722	0.865
	Creatinine	0.9 (0.2)	0.9 (0.2)	0.9 (0.2)	0.920	0.692	0.448
	Bilirubin	0.5 (0.2)	0.5 (0.3)	0.5 (0.2)	0.689	0.914	0.434
	ALT	9.3 (8.5)	11.9 (10.8)	11.5 (8.1)	0.294	0.432	0.962
	AST	21.9 (7.0)	22.0 (6.3)	21.9 (5.8)	0.998	0.999	0.994
	PTT	27.8 (2.3)	27.4 (2.4)	27.8 (2.2)	0.636	0.993	0.701
	INR	1.02 (0.05)	1.01 (0.06)	1.02 (0.06)	0.800	0.099	0.814
Knees	Hemoglobin	13.6 (1.5)	13.9 (1.5)	13.6 (1.3)	0.430	0.994	0.493
	Platelets (x 1,000)	257.8 (59.9)	240.0 (47.0)	244.5 (54.6)	0.153	0.346	0.888
	BUN	17.9 (5.0)	17.6 (5.4)	18.6 (5.7)	0.963	0.752	0.589
	Creatinine	0.8 (0.2)	0.9 (0.2)	0.9 (0.2)	0.434	0.143	0.786
	Bilirubin	0.4 (0.3)	0.5 (0.2)	0.5 (0.3)	0.416	0.934	0.638
	ALT	12.6 (12.6)	12.8 (12.0)	12.2 (9.7)	0.995	0.970	0.943
	AST	22.9 (8.7)	22.3 (8.0)	22.4 (6.6)	0.899	0.929	0.997
	PTT	27.6 (2.4)	28.5 (2.3)	27.8 (1.8)	0.067	0.872	0.192
	INR	1.00 (0.05)	1.02 (0.04)	1.02 (0.05)	0.217	0.289	0.985
Total cohort	Hemoglobin	13.7 (1.4)	13.9 (1.4)	13.7 (1.4)	0.464	0.921	0.259
	Platelets (x 1,000)	252.1 (56.5)	242.0 (50.1)	248.1 (51.2)	0.301	0.829	0.640
	BUN	17.6 (5.0)	17.6 (5.1)	18.3 (6.4)	1.000	0.542	0.536
	Creatinine	0.9 (0.2)	0.9 (0.2)	0.9 (0.2)	0.790	0.123	0.392
	Bilirubin	0.5 (0.3)	0.5 (0.2)	0.5 (0.2)	0.292	1.000	0.293
	ALT	11.1 (11.0)	12.4 (11.4)	11.8 (9.0)	0.600	0.853	0.905
	AST	22.4 (8.0)	22.2 (7.3)	22.1 (6.2)	0.946	0.943	1.000
	PTT	27.7 (2.3)	28.0 (2.4)	27.8 (2.0)	0.596	0.957	0.770
	INR	1.01 (0.06)	1.02 (0.05)	1.02 (0.06)	0.767	0.563	0.943

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