Table 2 Primary prophylaxis regimens

High/full-dose (Malmö/Swedish) [2]

25–40 IU kg⁻¹ 3 times a week or every other days starting at age 1–2 years, irrespective of bleeding history

Intermediate-dose (Dutch) [8]

15–25 IU kg⁻¹ 2–3 times per week, usually started after ≥1 hemarthrosis

Escalating-dose (Canadian) [9]

50 IU kg⁻¹ once a week, with dose increased to 30 IU kg⁻¹ twice a week, then 25 IU kg⁻¹ every other day, in response to bleeding frequency