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Table 2 Primary prophylaxis regimens

From: Individualized prophylaxis for optimizing hemophilia care: can we apply this to both developed and developing nations?

  Dosing
High/full-dose (Malmö/Swedish) [2] 25–40 IU kg−1 3 times a week or every other days starting at age 1–2 years, irrespective of bleeding history
Intermediate-dose (Dutch) [8] 15–25 IU kg−1 2–3 times per week, usually started after ≥1 hemarthrosis
Escalating-dose (Canadian) [9] 50 IU kg−1 once a week, with dose increased to 30 IU kg−1 twice a week, then 25 IU kg−1 every other day, in response to bleeding frequency