Fig. 2

Schematic representation of Dab2 functions in megakaryocytic differentiation and platelet activation. a Dab2 is upregulated during megakaryocytic differentiation of K562 cells, mESC and CD34⁺ hematopoietic stem cells and is involved in fibrinogen uptake during megakaryocytic differentiation. b Dab2 is present in the cytoplasm and α-granules of platelets. By interacting with the intracellular and extracellular portions of αIIbβ3 integrin, Dab2 regulates platelet aggregation and fibrinogen binding induced by various platelet agonists with the exception of thrombin which is the protease of Dab2. The cleavage of Dab2 by thrombin is protected when Dab2 is associated with sulfatide. c Dab2 regulates the inside-out signaling of mouse platelets stimulated by low concentrations of thrombin