Fig. 3
Comparison of the hemostatic ability of wild-type mice and hemophilia B mice whose endogenous factor IX was exchanged for FIXK5A. From: Cooley et al. Blood. 128:286. (2016). A mouse expressing FIXK5A from its endogenous promoter was compared to a wild-type mouse using the saphenous vein bleeding model. The activity level of the FIXK5A in the plasma of this mouse was slightly higher than that of the wild-type mouse. The mouse expressing FIXK5A nevertheless has a bleeding diathesis