Fig. 4

An examination of the ability of FIX (BeneFIX) to effect hemostasis 7 days post-infusion, after the ability of a first injury to effect clotting has been exhausted. From: Cooley et al. Blood. 128:286. (2016). Seven days post-infusion, the right saphenous vein was injured and the number of times that re-clotting ensued was determined. After the first injury was unable to continue clotting, the contralateral vein was injured and hemostatic efficacy was again measured. Presumably, any residual plasma FIX would have been used up during the first injury had plasma FIX been required for clotting