Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis

Thrombosis Journal

Table 1 Comparison of existing DIC diagnostic criteria

	JMHW	ISTH	JAAM
Underlying disease Clinical symptoms	1 p bleeding: 1 p organ failure: 1 p	0 p(essential) 0 p 0 p	0 p(essential) SIRS score ≥3: 1 p
Platelet count (X10⁴/μL)	8 < − ≤12 : 1 p 5 < − ≤8 : 2 p ≤5 : 3 p	5–10 : 1 p <5 : 2 p	8 - ≤12 or >30 % reduction/24 h: 1 p <8 or >50 % reduction/24 h: 3 p
Fibrin-related marker	FDP (μg/ml) 10 ≤ − <20: 1 p 20 ≤ − <40: 2 p ≥40 : 3 p	FDP, D-dimer, SF moderate increase: 2 p strong increase: 3 p	FDP (μg/ml) 10 ≤ − <25: 1 p ≥25 : 3 p
Fibrinogen (mg/dl)	100 < − ≤150: 1 p ≤100: 2 p	<100: 1 p	None
PT	PT ratio 1.25 ≤ − <1.67: 1 p ≥1.67: 2 p	Prolonged PT(sec) 3–6: 1 p >6: 2 p	PT ratio ≥1.2: 1 p
Diagnosis of DIC	≥7 p	≥5 p	≥4 p

p: points
JMHW: JMHW criteria; ISTH: JMHW criteria; JAAM: JMHW criteria; PT: prothrombin time
JMHW criteria: When there is leukemia/related diseases, aplastic anemia, or marked bone marrow megakaryocyte reduction, such as after administration of an anti-tumor agent, and a high degree of thrombocytopenia, the bleeding symptom and platelet count items should be calculated as 0 points, and DIC is diagnosed if the score is ≥4 points

ISSN: 1477-9560