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Table 5 Other tests relating to DIC diagnosis, and their significance

From: Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis

Test

Significance

Plasmin-α2 plasmin inhibitor complex (PIC)

The higher the values, the greater the fibrinolytic activation

α2 plasmin inhibitor (α2PI)

This is consumed and decreases due to fibrinolytic activation. However, it is also decreased by liver failure alone, and it is elevated in acute inflammatory diseases.

Protein C (PC)

Low values correlate with a poor prognosis. However, it is also decreased by vitamin K deficiency and/or liver failure alone.

Plasminogen activator inhibitor-1 (PAI-1)

High values in infectious-type DIC correlate with a poor prognosis.

HMGB-1

High values correlate with a poor prognosis.

e-XDP

Both low and markedly elevated values in infectious-type DIC correlate with a poor prognosis.