Skip to main content

Table 3 Examples of bleeding risk stratification for invasive procedures

From: Perioperative management of patients on direct oral anticoagulants

Minimal risk of bleeding or feasible with on-therapy levels of direct oral anticoagulantsa

Low to moderate risk of bleeding

High risk of bleeding

Tooth extraction: 1 to 3 teeth

Periodontology

Simple endoscopy without biopsy

Superficial surgery (e.g. abscess incision or minor dermatologic procedures (small superficial excision)

Cataract procedure

Double J stent insertion

Endoscopy with simple biopsy

Prostate or bladder biopsy

Coronary angiography

Simple abdominal hernia repair

Anal surgery

Gynecologic surgery: simple total laparoscopic hysterectomy

Orthopedic surgery: hand surgery, arthroscopy

Pace-maker or cardioverter-defibrillator implantationb

Neuraxial anesthesia

Intracranial surgery

Thoracic surgery

Cardiac surgery

Complex abdominal or gynecological cancer surgery

Major orthopedic surgery

Ear/Nose/Throat complex cancer surgery or specific surgery requiring good hemostasis (e.g. cochlear implant or thyroid surgery)

Liver and kidney biopsy

Transurethral prostate or bladder resection

Extracorporeal shockwave lithotripsy

Infected pace maker lead extraction (increased risk of cardiac tamponade)

Robotic surgery

  1. aWe suggest realizing these procedures at trough levels of direct oral anticoagulants (e.g. avoiding the intake the morning of the procedure)
  2. bAwaiting results of BRUISECONTROL-2 trial (NCT01675076) to decide whether device procedures can be safely realized on direct oral anticoagulants