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Table 2 Coagulation markers in supine and after 3 min head-up tilt (HUT) in 178 patients with unexplained syncope, mean ± SD or n (%)

From: Procoagulatory changes induced by head-up tilt test in patients with syncope: observational study

  All patients p-value* Men Women p-value¶
N (%) 178   81 (46) 97 (54)  
FVIII:C supine (kIE/L) 1.06 ± 0.38 0.43 1.07 ± 0.32 1.04 ± 0.41 0.56
FVIII:C HUT (kIE/L) 1.07 ± 0.36   1.07 ± 0.35 1.07 ± 0.36 0.98
VWF:Ag supine (kIE/L) 1.22 ± 0.54 <0.001 1.28 ± 0.56 1.17 ± 0.51 0.17
VWF:Ag HUT (kIE/L) 1.28 ± 0.55   1.33 ± 0.59 1.24 ± 0.52 0.31
VWF:GP1bA supine (kIE/L) 1.24 ± 0.55 0.20 1.30 ± 0.59 1.19 ± 0.52 0.19
VWF:GP1bA HUT (kIE/L) 1.26 ± 0.56   1.31 ± 0.64 1.23 ± 0.49 0.34
Fibrinogen supine (g/L) 2.75 ± 0.60 <0.001 2.67 ± 0.57 2.81 ± 0.62 0.11
Fibrinogen HUT (g/L) 2.84 ± 0.60   2.73 ± 0.59 2.93 ± 0.60 0.022
LA1 supine (sec) 31.2 ± 3.7 0.066 31.9 ± 3.50 30.7 ± 3.8 0.027
LA1 HUT (sec) 31.1 ± 4.7   32.0 ± 3.92 30.5 ± 5.2 0.030
APC-resistance supine 2.60 ± 0.41 <0.001 2.65 ± 0.39 2.57 ± 0.42 0.17
APC-resistance HUT 2.42 ± 0.43   2.49 ± 0.41 2.36 ± 0.44 0.044
APTT/C+ supine (sec) 84.3 ± 19.6 <0.001 85.8 ± 19.8 83.1 ± 19.5 0.36
APTT/C+ HUT (sec) 75.1 ± 18.8   77.4 ± 18.7 73.1 ± 18.7 0.13
APTT/C- supine (sec) 32.1 ± 3.8 <0.001 32.1 ± 4.1 32.1 ± 3.6 1.0
APTT/C- HUT (sec) 30.8 ± 3.7   30.8 ± 3.8 30.7 ± 3.7 0.83
  1. *supine vs. HUT paired samples t-test; ¶ men vs. women independent samples t-test; FVIII, factor VIII; VWF:Ag, von Willebrand factor antigen; vVWF:GP1bA, von Willebrand factor GP1bA activity; LA1, lupus anticoagulant-screening; APC-resistance, activated protein C resistance; APTT, activated prothrombin time; C+/−, with/without activated protein C