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Table 3 Gender-stratified changes in coagulation markers during head-up tilt among 178 patients with unexplained syncope

From: Procoagulatory changes induced by head-up tilt test in patients with syncope: observational study

 

Men

p-value*

Women

p-value*

N (%)

81 (46)

 

97 (54)

 

Δ FVIII:C (kIE/L)

0.00 ± 0.16

0.64

0.02 ± 0.13

0.091

Δ VWF:Ag (kIE/L)

0.04 ± 0.18

0.030

0.07 ± 0.15

<0.001

Δ VWF:GP1bA (kIE/L)

0.01 ± 0.25

0.86

0.03 ± 0.18

0.067

Δ Fibrinogen (g/L)

0.06 ± 0.32

0.12

0.12 ± 0.22

<0.001

Δ LA1 (sec)

−0.13 ± 3.23

0.72

−0.56 ± 1.96

0.007

Δ APC-resistance

−0.16 ± 0.26

<0.001

−0.21 ± 0.26

<0.001

Δ APTT/C+ (sec)

−8.3 ± 13.7

<0.001

−9.9 ± 10.6

<0.001

Δ APTT/C- (sec)

−1.2 ± 2.4

<0.001

−1.4 ± 1.7

<0.001

  1. *supine vs. HUT paired samples t-test; FVIII, factor VIII; VWF:Ag, von Willebrand factor antigen; vWF:GP1bA, von Willebrand factor GP1bA activity; LA1, lupus anticoagulant-screening; APC-resistance, activated protein C resistance; APTT, activated prothrombin time; C+/−, with/without activated protein C