Fatal pulmonary embolism following splenectomy in a patient with Evan’s syndrome: case report and review of the literature

Table 1 Case studies showing the type of thrombosis in patients undergoing splenectomy for hematological disorders

Study	Hematological disease	Type of thrombosis	Secondary thrombocytosis	Median interval to thrombosis	Patient outcome
Evans et al. [1]	12 ES	None	Present in 2 out of 12	N/A	N/A
NG et al. [2]	3 ES	None	Unknown	N/A	N/A
Silverstein et al. [25]	4 ES	Unknown	Unknown	Immediate post op	2 patients died
Michel et al. [26]	19 ES	None	Unknown	N/A	N/A
Boyle et al. [28]	1762 ITP	27 PSVT 75 VTE	Unknown	PSVT – 9.3 mo VTE – 20.9 mo	PSVT – 5 yr. survival 38% VTE – 5 yr. survival 62%
Van riet et al. [29]	4 HA	PSVT	Present	12 days	Unknown
Mohren et al. [31]	1 AIHA 1 ITP	PE & PSVT PE & PSVT	Present Present	8 days 7 days	Died Survived
Winslow et al. [32]	3 HA	PVT	Present	11 days	Survived
Allgood et al. [33]	47 AIHA		Unknown	Unknown
Stamou et al. [38]	1 AIHA	PSVT	Present	7 days	Survived
Tiede et al. [69]	1 ITP	PE	Unknown	30 days	Survived
Fujita et al. [41]	2 AIHA	PSVT	Present	16 days	Survived

ES Evan’s Syndrome, ITP Immune-mediate thrombocytopenic purpura, HA hemolytic anemia, AIHA autoimmune-mediate hemolytic anemia, PSVT portal splenic venous thrombosis, PE pulmonary embolus, DVT deep vein thrombosis, mo months, N/A not applicable

ISSN: 1477-9560