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Table 2 Coagulation parameters from V1 to V10

From: Four-factor prothrombin complex concentrate improves thrombin generation and prothrombin time in patients with bleeding complications related to rivaroxaban: a single-center pilot trial

Parameter

aPTT

QuickPT

ETP

Cmax

tlag

tmax

CTEXTEM

CTINTEM

Unit

sec

%

mE

mE min−1

sec

sec

sec

sec

Ref. range

26–37

70–130

312–441

111–156

19.6–25.6

50.8–72.0

42–78

134–218

V1

30 (6)

72 (16)

316 (75)

80 (31)*

52 (70)*

99 (67)*

94 (31)*

178 (37)

V2

28 (7)

92 (14)

524 (94)‡*

123 (25)

41 (12)*

95 (24)*

96 (34)*

198 (48)

V3

29 (6)

89 (11)

502 (104)‡*

114 (28)

39 (9)*

99 (29)*

91 (25)*

180 (41)

V4

33 (5)

87 (13)

518 (92)‡*

112 (26)

37 (7)*

93 (25)*

95 (25)*

193 (29)

V5

32 (6)

88 (15)

544 (102)‡*

127 (22)

33 (6)*

91 (25)*

83 (22)*

170 (37)

V6

32 (11)

83 (18)

528 (118)‡*

131 (31)

34 (9)*

83 (29)*

80 (17)*

176 (27)

V7

33 (6)

79 (13)

466 (72)‡*

115 (24)

31 (5)*

82 (16)*

82 (17)*

185 (32)

V8

31 (6)

88 (15)

411 (98)

111 (27)

27 (5)*

69 (16)

62 (15)

156 (37)

V9

34 (6)

96 (16)

380 (96)

95 (26) ‡*

28 (3)*

64 (4)

53 (20)

163 (28)

V10

29 (7)

88 (22)

371 (98)

103 (26)*

26 (4)*

59 (5)

70 (17)

156 (37)

  1. aPTT activated partial thromboplastin time, QuickPT Quick value, prothrombin time, mE milli extinctions, ETP endogenous thrombin potential, C max thrombin generation, peak thrombin generation; t lag thrombin generation, lag time until initiation, t max thrombin generation, time to peak thrombin activity, CT, ROTEM®, clotting time, EXTEM extrinsic coagulation pathway; INTEM, intrinsic clotting time. Wilcoxon signed-rank test was used to evaluate differences between baseline and samples from the same patient at V2-V10 (indicated as ). Values are indicated as mean values (+/− standard deviation). Highlighting: *out of reference range, significantly changed after PCC administration (as compared to V1)