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Table 2 Coagulation parameters from V1 to V10

From: Four-factor prothrombin complex concentrate improves thrombin generation and prothrombin time in patients with bleeding complications related to rivaroxaban: a single-center pilot trial

Parameter aPTT QuickPT ETP Cmax tlag tmax CTEXTEM CTINTEM
Unit sec % mE mE min−1 sec sec sec sec
Ref. range 26–37 70–130 312–441 111–156 19.6–25.6 50.8–72.0 42–78 134–218
V1 30 (6) 72 (16) 316 (75) 80 (31)* 52 (70)* 99 (67)* 94 (31)* 178 (37)
V2 28 (7) 92 (14) 524 (94)‡* 123 (25) 41 (12)* 95 (24)* 96 (34)* 198 (48)
V3 29 (6) 89 (11) 502 (104)‡* 114 (28) 39 (9)* 99 (29)* 91 (25)* 180 (41)
V4 33 (5) 87 (13) 518 (92)‡* 112 (26) 37 (7)* 93 (25)* 95 (25)* 193 (29)
V5 32 (6) 88 (15) 544 (102)‡* 127 (22) 33 (6)* 91 (25)* 83 (22)* 170 (37)
V6 32 (11) 83 (18) 528 (118)‡* 131 (31) 34 (9)* 83 (29)* 80 (17)* 176 (27)
V7 33 (6) 79 (13) 466 (72)‡* 115 (24) 31 (5)* 82 (16)* 82 (17)* 185 (32)
V8 31 (6) 88 (15) 411 (98) 111 (27) 27 (5)* 69 (16) 62 (15) 156 (37)
V9 34 (6) 96 (16) 380 (96) 95 (26) ‡* 28 (3)* 64 (4) 53 (20) 163 (28)
V10 29 (7) 88 (22) 371 (98) 103 (26)* 26 (4)* 59 (5) 70 (17) 156 (37)
  1. aPTT activated partial thromboplastin time, QuickPT Quick value, prothrombin time, mE milli extinctions, ETP endogenous thrombin potential, C max thrombin generation, peak thrombin generation; t lag thrombin generation, lag time until initiation, t max thrombin generation, time to peak thrombin activity, CT, ROTEM®, clotting time, EXTEM extrinsic coagulation pathway; INTEM, intrinsic clotting time. Wilcoxon signed-rank test was used to evaluate differences between baseline and samples from the same patient at V2-V10 (indicated as ). Values are indicated as mean values (+/− standard deviation). Highlighting: *out of reference range, significantly changed after PCC administration (as compared to V1)