Four-factor prothrombin complex concentrate improves thrombin generation and prothrombin time in patients with bleeding complications related to rivaroxaban: a single-center pilot trial

Table 3 Correlations between rivaroxaban concentrations and blood coagulation parameters

Individual values (left side, individual values for every single patient and for the respective test that was measured at every time point from V1 to V10) or mean values (right side, mean values of all patients and mean values of the measured rivaroxaban levels from V1 to V10) of all coagulation tests for all patients at every visit were correlated with the respective rivaroxaban concentrations at the same visit. The Pearson correlation was used to detect correlations between various blood coagulation tests and rivaroxaban concentrations. Tests were sorted according to the strength of correlation (r). Abbreviations: t_max thrombin generation, time to peak, CT, ROTEM® clotting time, EXTEM, ROTEM® extrinsic coagulation pathway, INTEM ROTEM®, intrinsic clotting time, Quick^PT Quick value (prothrombin time), C_max thrombin generation, peak thrombin generation, MCF ROTEM®, maximum clot firmness; t_lag thrombin generation, lag time until initiation, MaxV − t ROTEM®, time from reaction start until the maximum of the first derivate of the curve is reached, FIBTEM ROTEM®, fibrinogen-dependent coagulation, CFT ROTEM®, clot formation time, aPTT activated partial thromboplastin time, ETP endogenous thrombin potential

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