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Table 3 Correlations between rivaroxaban concentrations and blood coagulation parameters

From: Four-factor prothrombin complex concentrate improves thrombin generation and prothrombin time in patients with bleeding complications related to rivaroxaban: a single-center pilot trial

Individual values Mean values
parameter r p parameter r p
tmax 0.465 <0.001 tlag 0.924 <0.001
CTEXTEM 0.355 <0.001 CTEXTEM 0.916 <0.001
CTINTEM 0.296 0.002 tmax 0.902 <0.001
QuickPT −0.294 0.002 MaxV-tFIBTEM 0.887 0.001
Cmax −0.242 0.019 MaxV-tEXTEM 0.819 0.004
MCFEXTEM 0.238 0.015 MCFFIBTEM 0.779 0.008
tlag 0.222 0.027 CTINTEM 0.742 0.014
MaxV-tFIBTEM 0.221 0.128 FIclauss 0.701 0.024
MCFINTEM 0.203 0.037 MaxV-tINTEM 0.598 0.068
CFTEXTEM 0.194 0.047 FIimmun 0.579 0.080
MaxV-tEXTEM 0.172 0.242 ATIIIXa 0.533 0.112
CFTINTEM 0.139 0.156 MCFINTEM 0.423 0.224
aPTT 0.108 0.267 QuickPT 0.340 0.337
MaxV-tINTEM 0.070 0.635 CFTINTEM 0.328 0.355
ETP 0.025 0.809 CFTEXTEM 0.266 0.457
MCFFIBTEM 0.005 0.963 aPTT 0.185 0.609
  1. Individual values (left side, individual values for every single patient and for the respective test that was measured at every time point from V1 to V10) or mean values (right side, mean values of all patients and mean values of the measured rivaroxaban levels from V1 to V10) of all coagulation tests for all patients at every visit were correlated with the respective rivaroxaban concentrations at the same visit. The Pearson correlation was used to detect correlations between various blood coagulation tests and rivaroxaban concentrations. Tests were sorted according to the strength of correlation (r). Abbreviations: t max thrombin generation, time to peak, CT, ROTEM® clotting time, EXTEM, ROTEM® extrinsic coagulation pathway, INTEM ROTEM®, intrinsic clotting time, QuickPT Quick value (prothrombin time), C max thrombin generation, peak thrombin generation, MCF ROTEM®, maximum clot firmness; t lag thrombin generation, lag time until initiation, MaxV − t ROTEM®, time from reaction start until the maximum of the first derivate of the curve is reached, FIBTEM ROTEM®, fibrinogen-dependent coagulation, CFT ROTEM®, clot formation time, aPTT activated partial thromboplastin time, ETP endogenous thrombin potential