From: Differential impact of diabetes mellitus on antiplatelet effects of prasugrel and clopidogrel
Prasugrel | Clopidogrel | ||
---|---|---|---|
Variable | (n = 20) | (n = 20) | p-Value |
Age, yrs | 61.1 ± 11.0 | 66.1 ± 11.2 | 0.16 |
Male, n (%) | 17 (85) | 13 (65) | 0.14 |
Body mass index, kg/m2 | 27.4 ± 3.6 | 26.3 ± 4.3 | 0.37 |
Current Smoker, n (%) | 7 (35) | 4 (20) | 0.24 |
Hypertension, n (%) | 13 (65) | 17 (85) | 0.14 |
Dyslipidemia, n (%) | 15 (75) | 11 (55) | 0.19 |
Diabetes, n (%) | 8 (40) | 7 (35) | 0.74 |
SDB (ODI 3%), n (%) | 6 (30) | 6 (30) | 1.00 |
Previous MI, n (%) | 0 (0) | 0 (0) | 1.0 |
Previous AP, n (%) | 2 (10) | 1 (5) | 0.55 |
Previous PCI, n (%) | 2 (10) | 1 (5) | 0.55 |
Previous CABG, n (%) | 0 (0) | 0 (0) | 1.0 |
Previous stroke, n (%) | 1 (5) | 1 (5) | 1.0 |
PAD, n (%) | 0 (0) | 0 (0) | 1.0 |
Family History of CAD, n (%) | 8 (40) | 6 (30) | 0.51 |
LVEF, % | 69.9 ± 6.3 | 69.4 ± 6.2 | 0.74 |
eGFR, ml/min/1.73m2 | 65.8 ± 18.5 | 68.2 ± 17.2 | 0.68 |
Platelet counts, ×103/μL | 21.0 ± 5.9 | 20.0 ± 4.2 | 0.54 |
Medications | |||
Aspirin, n (%) | 20 (100) | 20 (100) | 1.00 |
PPI, n (%) | 15 (75) | 11 (55) | 0.19 |
OAD, n (%) | 8 (40) | 4 (20) | 0.17 |
Insulin therapy, n (%) | 0 (0) | 1 (5) | 0.31 |
Statins, n (%) | 15 (75) | 11 (55) | 0.19 |
Nitrates, n (%) | 6 (30) | 3 (15) | 0.26 |
CCB, n (%) | 9 (45) | 10 (50) | 0.75 |
ACEIs/ ARBs, n (%) | 11 (55) | 11 (55) | 1.00 |
Beta blockers, n (%) | 15 (75) | 12 (60) | 0.31 |