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Table 2 Sensitivity and specificity, PPV and NPV of a panel of coagulation tests for detecting > = 30 ng/mL dabigatran or rivaroxaban and correlation with the calibrated activity measurement of dabigatran or rivaroxaban

From: Detecting clinically relevant rivaroxaban or dabigatran levels by routine coagulation tests or thromboelastography in a cohort of patients with atrial fibrillation

  Dabigatran Rivaroxaban
Detection ≥30 ng/mL Sensitivity Specificity PPV NPV R2 Sensitivity Specificity PPV NPV R2
APTT Actin FSL 93 67 92 78 0.59 67 81 95 30 0.53
APTT Cephascreen 100 28 85 100 0.71 85 62 93 42 0.55
PT neoplastin 93 39 86 58 0.19 98 24 88 63 0.81
PT Innovin 49 78 90 27 0.09 68 67 92 27 0.26
TT Thrombin clotin 100 33 86 100 0.18
TT Thrombin 100 39 86 100 0.72
CT-INTEM ROTEM® 52 50 86 15 0.63 77 80 95 36 0.69
CT-EXTEM ROTEM® 91 75 86 15 0.51 96 75 96 75 0.58
  1. PPV Positive predictive value, NPV Negative predictive value, APTT Activated partial thrombin time, PT Prothrombin time, TT Thrombin time, CT Closure time