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Table 2 Sensitivity and specificity, PPV and NPV of a panel of coagulation tests for detecting > = 30 ng/mL dabigatran or rivaroxaban and correlation with the calibrated activity measurement of dabigatran or rivaroxaban

From: Detecting clinically relevant rivaroxaban or dabigatran levels by routine coagulation tests or thromboelastography in a cohort of patients with atrial fibrillation

 

Dabigatran

Rivaroxaban

Detection ≥30 ng/mL

Sensitivity

Specificity

PPV

NPV

R2

Sensitivity

Specificity

PPV

NPV

R2

APTT Actin FSL

93

67

92

78

0.59

67

81

95

30

0.53

APTT Cephascreen

100

28

85

100

0.71

85

62

93

42

0.55

PT neoplastin

93

39

86

58

0.19

98

24

88

63

0.81

PT Innovin

49

78

90

27

0.09

68

67

92

27

0.26

TT Thrombin clotin

100

33

86

100

0.18

TT Thrombin

100

39

86

100

0.72

CT-INTEM ROTEM®

52

50

86

15

0.63

77

80

95

36

0.69

CT-EXTEM ROTEM®

91

75

86

15

0.51

96

75

96

75

0.58

  1. PPV Positive predictive value, NPV Negative predictive value, APTT Activated partial thrombin time, PT Prothrombin time, TT Thrombin time, CT Closure time