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Table 1 The classification of trauma-induced coagulopathy

From: Activated protein C plays no major roles in the inhibition of coagulation or increased fibrinolysis in acute coagulopathy of trauma-shock: a systematic review

1. Physiological changes
 • Hemostasis and wound healing
2. Pathological changes
 • Endogenously induced primary pathologies
  - Disseminated Intravascular Coagulation (DIC)
   • Activation of coagulation
   • Insufficient anticoagulant mechanisms
   • Increased fibrin (ogen) olysis (early phase)
   • Suppression of fibrinolysis (late phase)
  - Acute coagulopathy trauma-shock (ACOTS)
   • Activated protein C-mediated suppression of coagulation
   • Activated protein C-mediated increased fibrinolysis
 • Exogenously induced secondary pathologies that modify DIC and ACOTS
  - Anemia-induced coagulopathy
  - Hypothermia-induced coagulopathy
  - Acidosis-induced coagulopathy
  - Dilutional coagulopathy
  - Others
  1. ACOTS is referred to by various names including (but not limited to) acute traumatic coagulopathy and acute coagulopathy of trauma, etc. Some researchers refer to ACOTS as trauma-induced coagulopathy. Adapted with permission from reference [22]