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Table 1 The classification of trauma-induced coagulopathy

From: Activated protein C plays no major roles in the inhibition of coagulation or increased fibrinolysis in acute coagulopathy of trauma-shock: a systematic review

1. Physiological changes

 • Hemostasis and wound healing

2. Pathological changes

 • Endogenously induced primary pathologies

  - Disseminated Intravascular Coagulation (DIC)

   • Activation of coagulation

   • Insufficient anticoagulant mechanisms

   • Increased fibrin (ogen) olysis (early phase)

   • Suppression of fibrinolysis (late phase)

  - Acute coagulopathy trauma-shock (ACOTS)

   • Activated protein C-mediated suppression of coagulation

   • Activated protein C-mediated increased fibrinolysis

 • Exogenously induced secondary pathologies that modify DIC and ACOTS

  - Anemia-induced coagulopathy

  - Hypothermia-induced coagulopathy

  - Acidosis-induced coagulopathy

  - Dilutional coagulopathy

  - Others

  1. ACOTS is referred to by various names including (but not limited to) acute traumatic coagulopathy and acute coagulopathy of trauma, etc. Some researchers refer to ACOTS as trauma-induced coagulopathy. Adapted with permission from reference [22]
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Thrombosis Journal

ISSN: 1477-9560

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