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Table 5 Studies that measure activated protein C-related coagulation and fibrinolysis markers

From: Activated protein C plays no major roles in the inhibition of coagulation or increased fibrinolysis in acute coagulopathy of trauma-shock: a systematic review

Reference (year) Design Patients (n) Inclusion criteria Injury Severity Score (ISS) Sampling time (n) Trauma-induced coagulopathy
Median (25–75% quartile)
[8] (2007) Prospective cohort (s) 208 Full trauma team activation 17(9–26) Arrival in the trauma room (1) Acute traumatic coagulopathy
[9] (2007) Prospective cohort (s) 39 Traumatic brain injury 24(14–30) Arrival in the trauma room (1) Coagulopathy
[10] (2008) Prospective cohort (s) 208 Major trauma 17(9–26) Immediately on admission to ED (1) Acute coagulopathy of trauma
[43] (2009) Prospective (s) 42 Initial blood sample collected within 1 h ACT
Non-ACT, not shown
Within 1 h of hospital presentation (1) Acute coagulopathy of trauma
[44] (2010) Prospective (s) 58 Not shown With coagulopathy
Without coagulopathy, not shown
Within 1 h of arrival at hospital Coagulopathy
[45] (2011) Prospective cohort (s) 334 Severe polytrauma
ISS > 15
ISS 15–20, 30–50, > 50 Immediately after ED admission (1) Trauma-induced coagulopathy
[46] (2013) Prospective cohort (s) 303 Trauma team activation Fibrinolytic activity by PAP and ML
Normal 6(1–10)
Moderate 17(9–28)
Severe 25(17–38)
Within 20 min of arrival in the ED (1) None
[47] (2014) Prospective cohort (s) 163 Highest-level trauma team activation Fibrinolytic activity by PAP
Normal 9(2–16)
Moderate 21(13–25)
Severe 28(17–35)
On admission and prior to administration blood product (1) None
[48] (2016) Prospective cohort (s) 72 Highest-level trauma team activation Hyperfibrinolytic by rapid TEG
33(22–41)
The earliest possible time point after injury (1) Trauma-induced coagulopathy