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Table 6 Studies that measure activated protein C-related coagulation and fibrinolysis markers

From: Activated protein C plays no major roles in the inhibition of coagulation or increased fibrinolysis in acute coagulopathy of trauma-shock: a systematic review

Reference (year)

Diagnosis

Control

Normal control

Thrombin (surrogate)

PAI-1

[8] (2007)

No

No

No

Yes

Yes

[9] (2007)

No

No

No

Yes

Yes

[10] (2008)

No

No

No

Yes

Yes

[43] (2009)

PT > 18 s (PTINR> 1.5)

Non-ACT

Healthy volunteer

Yes

No

[44] (2010)

ISTH DIC

Without coagulopathy

Healthy volunteer

Yes

No

[45] (2011)

NA

ISS 15–29

No

Yes

No

[46] (2013)

NA

Normal fibrinolytic activity

No

Yes

Yes

[47] (2014)

NA

Normal fibrinolysis

No

No

Yes

[48] (2016)

No

Healthy volunteer

Healthy volunteer

No

Yes