Table 1 Patient clinical features and outcomes
All (n = 39) | AT activity on day 0 | ||||
|---|---|---|---|---|---|
lower AT group AT < 80% (n = 10) | normal AT group AT ≥80% (n = 29) | P value | |||
Patient characteristics | |||||
Age | years | 61 (38–73) | 69 (57–80) | 56 (34–72) | 0.079 |
Sex: male / female | n (%) | 26 (66.7) / 13 (33.3) | 8 (80.0) / 2 (20.0) | 18 (62.1) / 11 (37.9) | 0.299 |
Injury Severity Score | 20 (10–27) | 26 (13–37) | 17 (10–26) | 0.091 | |
JAAM DIC (+) | n (%) | 11 (28.4) | 6 (60.0) | 5 (17.2) | 0.016 |
Duration of injury to blood sampling | |||||
min | 68 (31–180) | 71 (42–205) | 68 (30–187) | 0.469 | |
Laboratory data | |||||
Hemoglobin | g/L | 128 (118–136) | 116 (91–129) | 132 (120–140) | 0.035 |
Platelet | ×109/L | 216 (168–253) | 130 (86–246) | 220 (182–261) | 0.033 |
Prothrombin time (INR) | 1.07 (1.00–1.12) | 1.16 (1.10–1.33) | 1.03 (0.99–1.08) | < 0.001 | |
Activated partial thromboplastin time | sec | 24.7 (23.2–27.1) | 27.2 (26.1–34.0) | 24.3 (22.7–26.3) | 0.001 |
Hepaplastin test | % | 112.7 (91.6–126.8) | 93.2 (82.1–112.4) | 117.0 (96.3–127.8) | 0.088 |
Fibrinogen | g/L | 2.4 (1.9–2.8) | 1.8 (1.2–2.4) | 2.5 (2.3–2.8) | 0.024 |
FDP | μg/mL | 63.0 (31.4–168.1) | 161.3 (100.4–292.8) | 47.7 (22.6–111.7) | 0.005 |
D-dimer | μg/mL | 36.4 (16.0–96.6) | 92.0 (53.5–136.5) | 21.6 (10.7–59.1) | 0.010 |
TAT | μg/L | 88.0 (30.1–200.0) | 99.4 (74.7–200.5) | 64.0 (21.1–200.0) | 0.403 |
PIC | μg/mL | 9.1 (2.8–17.8) | 15.1 (7.7–23.6) | 5.8 (2.2–14.3) | 0.022 |
tPAI-1 | ng/mL | 30 (3–602) | 27 (19.7–113.3) | 29 (16–47.5) | 0.551 |
AT activity | % | 96.2 (79.8–108.3) | 69.9 (66.2–76.9) | 102.5 (91.1–109.7) | < 0.001 |
Protein C | % | 90.6 (75.8–101.5) | 69.5 (54.6–83.0) | 95.3 (82.1–108.8) | 0.001 |
α2-plasmin inhibitor | % | 90.5 (79.6–101.6) | 73.8 (62.6–81.8) | 95.8 (85.1–105.6) | < 0.001 |
Plasminogen | % | 93.8 (81.5–102.6) | 81.4 (64.0–88.2) | 99.7 (86.9–106.7) | 0.003 |
Thrombomodulin | ng/mL | 2.9 (2.3–3.7) | 3.9 (2.5–5.0) | 2.9 (2.3–3.7) | 0.076 |
Interleukin-6a | pg/mL | 108.5 (40.8–250.3) | 241.0 (145.5–411.0) | 69.5 (33.0–175.5) | 0.004 |
Lactate acid | mmol/L | 1.7 (1.2–2.4) | 2.2 (1.1–2.9) | 1.7 (1.2–2.1) | 0.281 |
Albumin | g/L | 39 (34–43) | 31 (29–36) | 42 (38–43) | < 0.001 |
Transfusion Day 0 / Day 0–6 | |||||
Packed red blood cells | mL | 0 (0–0) / 0 (0–560) | 140 (0–560) / 280 (280–770) | 0 (0–0) / 0 (0–0) | 0.094 / 0.011 |
Fresh frozen plasma | mL | 0 (0–480) / 0 (0–480) | 480 (0–840) / 480 (0–1680) | 0 (0–0) / 0 (0–0) | 0.015 / 0.018 |
Platelets | mL | 0 (0–0) / 0 (0–0) | 0 (0–0) / 0 (0–100) | 0 (0–0) / 0 (0–0) | 0.640 / 0.014 |
Intervention Day 0 / Day 0–6 | |||||
Interventional radiology | n (%) | 6 (15.3) / 6 (15.3) | 3 (30.0) / 3 (30.0) | 3 (10.3) / 3 (10.3) | 0.162 / 0.162 |
Craniotomy | n (%) | 3 (7.6) / 3 (7.6) | 1 (10.0) / 1 (10.0) | 2 (6.8) / 2 (6.8) | 0.600 / 0.600 |
Laparotomy | n (%) | 1 (2.5) / 1 (2.5) | 1 (10.0) / 1 (10.0) | 0 (0.0) / 0 (0.0) | 0.256 / 0.256 |
Open reduction and Internal fixation | n (%) | 0 (0.0) / 14 (35.9) | 0 (0.0) / 4 (40.0) | 0 (0.0) / 10 (34.4) | none / 0.519 |
Outcome | |||||
DVT (+) | n (%) | 6 (15.4) | 2 (20.0) | 4 (13.7) | 0.490 |
In-hospital Mortality | n (%) | 2 (5.1) | 0 (0.0) | 2 (6.8) | 0.547 |