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Table 1 JAAM criteria [11] and ISTH overt DIC criteria [22]

From: Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective study

Ā 

JAAM

ISTH

Score

1

3

1

2

3

SIRS

ā‰„3 items

Ā Ā Ā Ā 

Platelet Count (103/mL)

ā‰„80 andā€‰<ā€‰120, orā€‰>ā€‰30% decrease within 24Ā h

<ā€‰80 or 50% decrease within 24Ā h

<ā€‰100

<ā€‰50

Ā 

FDP (Ī¼g/mL)

ā‰„10 andā€‰<ā€‰25

ā‰„25

Ā 

ā‰„10 andā€‰<ā€‰25

(Moderate increase)

ā‰„25

(Strong increase)

PT Ratio

ā‰„1.2

Ā Ā Ā Ā 

Prolonged prothrombin time (sec)

Ā Ā 

3<, <ā€‰6

6<

Ā 

Fibrinogen level (g/L)

Ā Ā 

<ā€‰1.0

Ā Ā 

Diagnosis

4 points or more

5 points or more

  1. These score was assessed using d-dimer if FDP was not measured. The cut off value of d-dimer level were ā€œmoderate increase; 5.4ā€“13.2Ā Ī¼g/mL, strong increase; ā‰„13.2Ā Ī¼g/mLā€
  2. JAAM: The revised Japanese Association for Acute Medicine
  3. ISTH: The International Society on Thrombosis and Haemostasis
  4. SIRS: systemic inflammatory response syndrome
  5. Criteria for SIRS (systemic inflammatory response syndrome)
  6. ā€¢ Temperature: >ā€‰38Ā Ā°C orā€‰<ā€‰36Ā Ā°C
  7. ā€¢ Heart rate: >ā€‰90 beats/min
  8. ā€¢ Respiratory rate: >ā€‰20 breath /min or PaCO2ā€‰<ā€‰32Ā Torr (<ā€‰4.3Ā kPa)
  9. ā€¢ White cell blood counts: >ā€‰12,000/mm3, <ā€‰4,000cells/mm3, or 10% immature (band) forms