Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin

Table 1 Background characteristics of the patients with sepsis-associated DIC

Case	1	2	3	4	5	6	7	8
Age	69	39	72	65	64	71	67	81
Sex	F	M	M	M	M	M	M	M
Site of infection	Abd	Pulm	Pulm	Abd	Abd	Pulm	Abd	Pulm
APACHE II	7	13	21	36	28	23	30	22
SOFA	5	7	11	13	18	12	13	9
SIRS	4	3	3	3	4	3	4	2
DIC score	5	8	5	4	8	8	5	5
AT activity	78	80	58	44	33	74	55	77
Concomitant anticoagulants		NM	AT NM	AT NM	AT NM	AT	AT NM	NM
Outcome	Alive	Alive	Dead	Alive	Dead	Alive	Alive	Dead

F female, M male, Abd abdominal, Pulm pulmonary, APACHE acute physiology and chronic health evaluation, SOFA sequential organ failure assessment, SIRS systemic inflammatory response syndrome, DIC disseminated intravascular coagulation, AT antithrombin, NM nafamostat mesilate
APACHE II score was evaluated on the first day of intensive care unit admission. Overall prognosis was evaluated on day 28 after rTM treatment. All other parameters, including SIRS score, SOFA score, DIC score, and AT activity, were evaluated on the first day of rTM treatment

ISSN: 1477-9560