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Table 1 Summary statistics

From: Sickle cell disease, sickle trait and the risk for venous thromboembolism: a systematic review and meta-analysis

Outcome N studies Population Odds ratio (95%CI) P value H (95%CI) I2 (95%CI) P heterogeneity P Harbord test
SCD versus Control
 VTE 3 Adults 4.43 (2.62–7.48) <.0001 1.0 (1.0–2.8) 0.0 (0.0–87.3) .440 .467
 DVT 1 Adults 1.12 (1.09–1.15) <.0001 NA NA NA NA
 PE 2 Adults 3.66 (3.57–3.75) <.0001 1.0 0.0 0.588 NA
 VTE 1 Pregnant and PP women 33.16 (9.70–113.37) <.0001 NA NA NA NA
 DVT 1 Pregnant women 30.66 (1.63–578.15) .022 NA NA NA NA
SCD versus SCT
 VTE 3 Adults 3.09 (1.79–5.33) <.0001 1.0 (1.0–2.2) 0.0 (0.0–79.8) .598 .524
 PE 1 Adults 3.14 (1.67–5.92) .0004 NA NA NA NA
 VTE 1 Pregnant and PP women 20.34 (4.05–102.05) .0003 NA NA NA NA
SCT versus Control
 VTE 4 Adults 1.71 (1.34–2.18) <.0001 1.0 (1.0–2.5) 0.0 (0.0–83.5) .427 .238
 DVT 3 Adults 1.23 (0.92–1.65) .157 1.0 (1.0–1.5) 0.0 (0.0–55.7) .791 .810
 PE 3 Adults 2.12 (1.18–3.80) .012 2.3 (1.3–4.0) 80.6 (39.0–93.8) .006 .405
 VTE 2 Pregnant and PP women 0.90 (0.28–2.89) .863 1.48 47.5 0.168 NA
  1. CI confidence interval, DVT deep venous thrombosis, VTE venous thromboembolism, PE pulmonary embolism, PP postpartum, SCD, sickle cell disease, SCT sickle cell trait, NA not applicable