Table 1 Summary statistics
Outcome | N studies | Population | Odds ratio (95%CI) | P value | H (95%CI) | I2 (95%CI) | P heterogeneity | P Harbord test |
|---|---|---|---|---|---|---|---|---|
SCD versus Control | ||||||||
VTE | 3 | Adults | 4.43 (2.62–7.48) | <.0001 | 1.0 (1.0–2.8) | 0.0 (0.0–87.3) | .440 | .467 |
DVT | 1 | Adults | 1.12 (1.09–1.15) | <.0001 | NA | NA | NA | NA |
PE | 2 | Adults | 3.66 (3.57–3.75) | <.0001 | 1.0 | 0.0 | 0.588 | NA |
VTE | 1 | Pregnant and PP women | 33.16 (9.70–113.37) | <.0001 | NA | NA | NA | NA |
DVT | 1 | Pregnant women | 30.66 (1.63–578.15) | .022 | NA | NA | NA | NA |
SCD versus SCT | ||||||||
VTE | 3 | Adults | 3.09 (1.79–5.33) | <.0001 | 1.0 (1.0–2.2) | 0.0 (0.0–79.8) | .598 | .524 |
PE | 1 | Adults | 3.14 (1.67–5.92) | .0004 | NA | NA | NA | NA |
VTE | 1 | Pregnant and PP women | 20.34 (4.05–102.05) | .0003 | NA | NA | NA | NA |
SCT versus Control | ||||||||
VTE | 4 | Adults | 1.71 (1.34–2.18) | <.0001 | 1.0 (1.0–2.5) | 0.0 (0.0–83.5) | .427 | .238 |
DVT | 3 | Adults | 1.23 (0.92–1.65) | .157 | 1.0 (1.0–1.5) | 0.0 (0.0–55.7) | .791 | .810 |
PE | 3 | Adults | 2.12 (1.18–3.80) | .012 | 2.3 (1.3–4.0) | 80.6 (39.0–93.8) | .006 | .405 |
VTE | 2 | Pregnant and PP women | 0.90 (0.28–2.89) | .863 | 1.48 | 47.5 | 0.168 | NA |