Fig. 3

Activated partial thromboplastin time changes from baseline for all ages and all doses with (a) rivaroxaban tablet and (b) rivaroxaban suspension. Light grey dots are data points from healthy adult volunteers; coloured dots represent individual data from children. A linear relationship was assumed for the concentration–response curve. 99% prediction intervals were used to depict the variability in the pooled data. The two reference populations consist of healthy adult volunteers from phase I trials, who received either a single dose of rivaroxaban 10 mg (age 18–40 years, n = 171), or a single dose of rivaroxaban 20 mg (age 18–40 years, n = 101). aPTT change from baseline (x-fold) is individual aPTT at a distinct time point, divided by individual aPTT prior to drug administration. aPPT, activated partial thromboplastin time; eq., equivalent