Table 4 Classification of risk factors for venous thrombosis at baseline
Subgroup | Requirement | |
|---|---|---|
Provoked by persistent risk factor | ||
Active cancer – n (%) | • Hematologic malignancies • Solid tumors | Diagnosed, or treated within 3 months, or presence of metastases |
Major organ disease – n (%) | • Cardiac • Gastrointestinal • Renal • Neurological | Exclude major infectious disease |
Major congenital venous anomaly – n (%) | Venous anomaly in relation to location of index event | |
Known inherited thrombophilia – n (%) • Antithrombin, protein C or protein S deficiency • Factor V Leiden, or prothrombin mutation | • Homozygous • Heterozygous | At baseline or confirmed after randomization |
Acquired thrombophilia – n (%) | Antiphospholipid syndrome. At baseline or confirmed after randomization | |
Family history of venous thrombosis – n (%) | First degree (parent or sibling) | |
Morbid obesity – n (%) | Body mass index > 35 kg/m2 | |
Provoked by transient risk factor | ||
Major surgery – n (%) | Timeframe: within 1 month | |
Major trauma – n (%) | Timeframe: within 1 month | |
Major infectious disease – n (%) | • Systemic • Local | Timeframe: within 1 month Local infection in anatomical relation with index event |
Prolonged immobilization – n (%) | Timeframe: within 1 month Duration immobilization > 1 week | |
Central venous catheter – n (%) | Timeframe: within 1 month Location of index event related to central venous catheter | |
Use of estrogens or progestins – n (%) | ||
Puerperium– n (%) | Puerperium ends 6 weeks after birth | |
Etiology of index venous thrombosis | ||
Unprovoked – n (%) Provoked by persistent risk factor – n (%) Provoked by transient risk factor – n (%) Provoked by persistent and transient risk factor – n (%) | ||
Number of risk factors – n (%) 0 1 ≥2 | ||