Assumed rivaroxaban–standard anticoagulation hazard ratio

Assumed 95% CI if incidence of the main efficacy outcome is 2.0% on standard anticoagulation^{a}

Assumed 95% CI if incidence of the secondary efficacy outcome is 10% on standard anticoagulation^{a}


0.500

0.11–2.28

0.25–0.99

0.667

0.16–2.76

0.35–1.26

0.800

0.20–3.14

0.43–1.48

0.930

0.25–3.52

0.51–1.69

1.000

0.27–3.72

0.56–1.80

1.075

0.29–3.94

0.60–1.92

1.250

0.35–4.45

0.71–2.21

1.500

0.43–5.18

0.86–2.61

2.000

0.60–6.64

1.17–3.42

 Hypothetical 95% CIs around various hazard ratios assuming an incidence of 2.0% for the main efficacy outcome and 10% for the secondary efficacy outcome in the standard anticoagulation group in a population of 500 children randomized to rivaroxaban or standard anticoagulation in a 2 to 1 fashion. ^{a}Based on approximation, CI, confidence intervals