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Fig. 2 | Thrombosis Journal

Fig. 2

From: Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases

Fig. 2

Proteolytic PAR cleavage. a N-terminal sequences of human PARs (PAR1–4) containing potential cleavage sites. b Proteolytic cleavage of PARs by soluble exogenous proteases exposes new N-terminal sequences that serve as tethered ligands for G protein dependent activation of receptors. Alternatively, proteolytic cleavage at other sites destroys the function of the receptor to prevent intracellular signal transduction

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