Table 1 PAR1 cleaving proteases

Mammalian proteases

Thrombin

R⁴¹S⁴²

aPC

R⁴⁶N⁴⁷

R⁴¹S⁴²

FVIIa

unknown

FXa

R⁴¹S⁴²

Trypsin

R⁴¹S⁴²

Chymase

unknown

MMP-1

D³⁹P⁴⁰, L⁴⁴L⁴⁵, F⁸⁷I⁸⁸

N⁴⁷P⁴⁸, R⁷⁰L⁷¹,K⁸²Q⁸³

MMP-2

L³⁸D³⁹

MMP-3,-8,-9

R⁴¹S⁴²

MMP-12

unknown

MMP-13

S⁴²F⁴³

L³⁸T³⁹, mouse

Cathepsin G

R⁴¹S⁴², F⁵⁵W⁵⁶, Y⁶⁹R⁷⁰

Neutrophil elastase

A³⁶T³⁷, V⁷²S⁷³, A⁸⁶F⁸⁷

Proteinase-3

A³⁶T³⁷, P⁴⁸N⁴⁹, V⁷²S⁷³, A⁹²S⁹³

Plasmin

K³²A³³, R⁴¹S⁴², R⁷⁰ L⁷¹, K⁷⁶ S⁷⁷, K⁸² Q⁸³

Kallikrein-4,-5,-6

unknown

Kallikrein-14

R⁴⁶N⁴⁷

Granzyme A,B, K

unknown

Calpain-1

K³²A³³, S⁷⁶K⁷⁷

Non-mammalian proteases

PA-BJ

R⁴¹S⁴², R⁴⁶N⁴⁷

Thrombocytin

R⁴¹S⁴², R⁴⁶N⁴⁷

DerP1

unknown

Gingipain R

R⁴¹S⁴²

SpeB

L⁴⁴L⁴⁵

LepA

unknown

S.pneumoniae proteases

unknown

Thermolysin

F⁴³L⁴⁴, L⁴⁴L⁴⁵

penC

R⁴¹S⁴²