Table 1 PAR1 cleaving proteases
| Protease | Major cleavage site | Additional cleavage sites | |
|---|---|---|---|
| Mammalian proteases | Thrombin | R41S42 | |
| aPC | R46N47 | R41S42 | |
| FVIIa | unknown | ||
| FXa | R41S42 | ||
| Trypsin | R41S42 | ||
| Chymase | unknown | ||
| MMP-1 | D39P40, L44L45, F87I88 | N47P48, R70L71,K82Q83 | |
| MMP-2 | L38D39 | ||
| MMP-3,-8,-9 | R41S42 | ||
| MMP-12 | unknown | ||
| MMP-13 | S42F43 | L38T39, mouse | |
| Cathepsin G | R41S42, F55W56, Y69R70 | ||
| Neutrophil elastase | A36T37, V72S73, A86F87 | ||
| Proteinase-3 | A36T37, P48N49, V72S73, A92S93 | ||
| Plasmin | K32A33, R41S42, R70 L71, K76 S77, K82 Q83 | ||
| Kallikrein-4,-5,-6 | unknown | ||
| Kallikrein-14 | R46N47 | ||
| Granzyme A,B, K | unknown | ||
| Calpain-1 | K32A33, S76K77 | ||
| Non-mammalian proteases | PA-BJ | R41S42, R46N47 | |
| Thrombocytin | R41S42, R46N47 | ||
| DerP1 | unknown | ||
| Gingipain R | R41S42 | ||
| SpeB | L44L45 | ||
| LepA | unknown | ||
| S.pneumoniae proteases | unknown | ||
| Thermolysin | F43L44, L44L45 | ||
| penC | R41S42 |