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Table 2 PAR2 cleaving proteases

From: Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases

 

Protease

Major cleavage site

Additional cleavage sites

Mammalian proteases

Thrombin

R36S37

 

aPC

unknown

 

FXa

R36S37

 

Trypsin

R36S37

K34G35, K51G52, K72L73

Tryptase

R36S37

 

Chymase

G35R36

L38I39, mouse

Matriptase

R36S37

 

Cathepsin G

F65S66

F59S60, F64S65

Cathepsin S

G40K41

E56P57, mouse

Neutrophil elastase

A66S67, S67V68

V42D43,V48T49,V53T54,V58T59,T74T75,V76F77

Proteinase-3

D62E63

V48T49,V55E56,T57V58 V61D62,K72L73,T74T75,T75V76,V76F77

Plasmin

R36S37

K34G35

Testisin

unknown

 

Kallikrein-4,

unknown

 

Kallikrein-5,-6,-14

R36S37

 

Calpain-2

unknown

 

Non-mammalian proteases

Der-P1,-P2,-P3,-P9

unknown

 

Cockroach E1-E3

R36S37

 

Gingipain R

unknown

 

LepA

unknown

 

EPa

S37L38

S38L39, rat

S.pneumoniae proteases

unknown

 

Thermolysin

unknown

 

Serralysin

unknown

 

P.acnes proteases

unknown

 

aPA

unknown

 

Bromelain

unknown

 

Ficin

unknown

 

Papain

unknown

 

penC

R36S37

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