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Table 2 PAR2 cleaving proteases

From: Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases

  Protease Major cleavage site Additional cleavage sites
Mammalian proteases Thrombin R36S37  
aPC unknown  
FXa R36S37  
Trypsin R36S37 K34G35, K51G52, K72L73
Tryptase R36S37  
Chymase G35R36 L38I39, mouse
Matriptase R36S37  
Cathepsin G F65S66 F59S60, F64S65
Cathepsin S G40K41 E56P57, mouse
Neutrophil elastase A66S67, S67V68 V42D43,V48T49,V53T54,V58T59,T74T75,V76F77
Proteinase-3 D62E63 V48T49,V55E56,T57V58 V61D62,K72L73,T74T75,T75V76,V76F77
Plasmin R36S37 K34G35
Testisin unknown  
Kallikrein-4, unknown  
Kallikrein-5,-6,-14 R36S37  
Calpain-2 unknown  
Non-mammalian proteases Der-P1,-P2,-P3,-P9 unknown  
Cockroach E1-E3 R36S37  
Gingipain R unknown  
LepA unknown  
EPa S37L38 S38L39, rat
S.pneumoniae proteases unknown  
Thermolysin unknown  
Serralysin unknown  
P.acnes proteases unknown  
aPA unknown  
Bromelain unknown  
Ficin unknown  
Papain unknown  
penC R36S37