Table 2 PAR2 cleaving proteases
| Protease | Major cleavage site | Additional cleavage sites | |
|---|---|---|---|
| Mammalian proteases | Thrombin | R36S37 | |
| aPC | unknown | ||
| FXa | R36S37 | ||
| Trypsin | R36S37 | K34G35, K51G52, K72L73 | |
| Tryptase | R36S37 | ||
| Chymase | G35R36 | L38I39, mouse | |
| Matriptase | R36S37 | ||
| Cathepsin G | F65S66 | F59S60, F64S65 | |
| Cathepsin S | G40K41 | E56P57, mouse | |
| Neutrophil elastase | A66S67, S67V68 | V42D43,V48T49,V53T54,V58T59,T74T75,V76F77 | |
| Proteinase-3 | D62E63 | V48T49,V55E56,T57V58 V61D62,K72L73,T74T75,T75V76,V76F77 | |
| Plasmin | R36S37 | K34G35 | |
| Testisin | unknown | ||
| Kallikrein-4, | unknown | ||
| Kallikrein-5,-6,-14 | R36S37 | ||
| Calpain-2 | unknown | ||
| Non-mammalian proteases | Der-P1,-P2,-P3,-P9 | unknown | |
| Cockroach E1-E3 | R36S37 | ||
| Gingipain R | unknown | ||
| LepA | unknown | ||
| EPa | S37L38 | S38L39, rat | |
| S.pneumoniae proteases | unknown | ||
| Thermolysin | unknown | ||
| Serralysin | unknown | ||
| P.acnes proteases | unknown | ||
| aPA | unknown | ||
| Bromelain | unknown | ||
| Ficin | unknown | ||
| Papain | unknown | ||
| penC | R36S37 |