Thrombosis Journal

Table 4 PAR4 cleaving proteases

From: Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases

	Protease	Major cleavage site	Additional cleavage sites
Mammalian proteases	Thrombin	R⁴⁷G⁴⁸
	Trypsin	R⁴⁷G⁴⁸
	Cathepsin G	R⁴⁷G⁴⁸
	Kallikrein-14	unknown
Non-mammalian proteases	PA-BJ	R⁴⁷G⁴⁸
	Thrombocytin	R⁴⁷G⁴⁸
	Der-P3	unknown
	Gingipain R	R⁴⁷G⁴⁸
	LepA	unknown
	S.pneumoniae proteases	unknown
	Bromelain	unknown
	Ficin	unknown
	Papain	unknown

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ISSN: 1477-9560

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