|
Peptide
|
Agonist
|
GYPGQV/−NH2
|
Human, Rat
|
Induces platelet activation [144]
|
|
GYPGKF/−NH2
|
Human, Rat
|
Induces platelet activation [144]
|
|
AYPGKF/−NH2
|
Human, Mouse
|
Induces platelet activation [145]
|
|
Peptidomimetic
|
Antagonist
|
tc-YGPKF
|
Rat
|
Blocks thrombin and PAR4-AP induced platelets aggregation [321]
|
|
Non-peptide small molecule
|
Antagonist
|
YD-3
|
Human
|
Blocks thrombin induced platelet activation [282, 322,323,324,325]
|
|
Mouse, Rat, Rabbit
|
Blocks thrombin and PAR4-AP induced platelets activation [323,324,325]
|
|
ML-354
|
Human
|
Blocks PAR4-AP induced platelet activation [326,327,328]
|
|
BMS-986120
|
Human
|
Blocks PAR4-AP induced calcium release and platelet activation [329]
|
|
Human
|
Blocks thrombus formation at high shear stress [277]
|
|
Monkey
|
Blocks platelet activation [329]
|
|
Pepducin
|
Antagonist
|
P4pal-10
|
Human, Mouse
|
Blocks thrombin and PAR4-AP induced platelet activation [268]
|
|
Rat
|
Blocks thrombin and PAR4-AP induced platelets activation [330]
|
|
P4pal-i1
|
Human
|
Blocks PAR4 induced platelets activation [150]
|
