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Table 7 PAR4 signaling modulators
| Class | Agonist/ Antagonist | Name | Receptor/Cell/Tissue type | Cellular response |
|---|---|---|---|---|
| Peptide | Agonist | GYPGQV/−NH2 | Human, Rat | Induces platelet activation [144] |
| GYPGKF/−NH2 | Human, Rat | Induces platelet activation [144] | ||
| AYPGKF/−NH2 | Human, Mouse | Induces platelet activation [145] | ||
| Peptidomimetic | Antagonist | tc-YGPKF | Rat | Blocks thrombin and PAR4-AP induced platelets aggregation [321] |
| Non-peptide small molecule | Antagonist | YD-3 | Human | Blocks thrombin induced platelet activation [282, 322,323,324,325] |
| Mouse, Rat, Rabbit | Blocks thrombin and PAR4-AP induced platelets activation [323,324,325] | |||
| ML-354 | Human | Blocks PAR4-AP induced platelet activation [326,327,328] | ||
| BMS-986120 | Human | Blocks PAR4-AP induced calcium release and platelet activation [329] | ||
| Human | Blocks thrombus formation at high shear stress [277] | |||
| Monkey | Blocks platelet activation [329] | |||
| Pepducin | Antagonist | P4pal-10 | Human, Mouse | Blocks thrombin and PAR4-AP induced platelet activation [268] |
| Rat | Blocks thrombin and PAR4-AP induced platelets activation [330] | |||
| P4pal-i1 | Human | Blocks PAR4 induced platelets activation [150] |
