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Table 2 Parameters of haematologic data, CGMs and T-TAS before and after glycemic control in STUDY 1

From: Effects of glycemic control and hypoglycemia on Thrombus formation assessed using automated microchip flow chamber system: an exploratory observational study

 

Baseline

After control

P-value

FPG (mM)

9.6 ± 2.3

6.3 ± 1.4

0.004

Hematologic parameters

 WBC count (/μL)

5752 ± 1440

5468 ± 1342

0.191

 Ht (%)

41.1 ± 4.8

40.7 ± 4.9

0.523

 Plt count (104 /μL)

19.3 (16.6–24.2)

20.2 (18.9–24.1)

0.683

 PAI-1 (ng/mL)

24.0 (16.3–45.3)

21.0 (14.5–28.5)

0.211

 Fibrinogen (g/dL)

3.3 ± 0.7

3.6 ± 0.3

0.128

 Factor VII (%)

85.4 ± 8.6

83.6 ± 11.2

0.522

 Factor VIII (%)

101.1 ± 33.4

92.3 ± 28.7

0.288

 F1 + 2 (pM)

135.5 (105.0–169.3)

139.5 (107.3–173.5)

0.580

CGMs

 Mean PG (mM)

10.1 ± 2.5

6.8 ± 0.9

0.005

 Peak PG (mM)

16.3 (11.3–19.1)

10.2 (8.8–12.4)

0.017

 SD (mM)

1.8 (1.2–2.4)

1.1 (0.9–1.7)

0.242

 MAGE (mM)

4.3 (2.9–7.0)

2.8 (2.2–4.1)

0.310

T-TAS

 PL-T10 (s)

125.5 (110.8–141.0)

126.0 (120.5–135.3)

0.881

 PL-OT (s)

327.8 ± 67.6

308.7 ± 56.5

0.166

 PL-AUC10 (kPa × min)

393.2 ± 45.3

398.3 ± 32.2

0.647

  1. Values are presented as mean ± standard deviation (SD) or median (quartile range)
  2. WBC white blood cell, Ht hematocrit, Plt platelet, PAI-1 plasminogen activator inhibitor-1, F1 + 2 prothrombin fragment 1 + 2, FPG fasting plasma glucose, MAGE mean amplitude of glycemic excursions, T10 time to 10 kPa, OT occlusion time, AUC10 area under the curve in 10 min