Table 4 Pharmacokinetic parameters of edoxaban
Group 1 30 mg edoxaban plus 2.5 mg prasugrel | Group 2 30 mg edoxaban plus 3.75 mg prasugrel | |||
|---|---|---|---|---|
n = 12 | n = 12 | |||
Edoxaban alone | Edoxaban plus prasugrel | Edoxaban alone | Edoxaban plus prasugrel | |
Cmax,ss(ng/mL) | ||||
Mean (SD) | 216.0 (112.4) | 216.0 (80.4) | 191.4 (79.7) | 216.9 (68.1) |
Median (IQR) | 199.8 (127.6–300.5) | 187.8 (169.0–298.3) | 170.5 (134.5–237.3) | 216.6 (157.3–269.3) |
AUCtau,ss(ng h/mL) | ||||
Mean (SD) | 1059.4 (228.0) | 1068.6 (189.8) | 1070.4 (239.7) | 1088.5 (223.2) |
Median (IQR) | 1025.0 (924.2–1152.4) | 1005.8 (912.2–1216.7) | 992.5 (953.1–1206.7) | 1049.6 (930.4–1240.1) |
tmax,ss(h) | ||||
Mean (SD) | 1.2 (0.96) | 0.92 (0.70) | 1.0 (0.84) | 0.71 (0.26) |
Median (IQR) | 0.75 (0.50–1.5) | 0.75 (0.50–1.0) | 0.50 (0.50–1.5) | 0.50 (0.50–1.0) |