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Table 3 Main results of pooled ORs in meta-analysis of FVL 1691G > A mutation

From: Factor V Leiden 1691G > A mutation and the risk of recurrent pregnancy loss (RPL): systematic review and meta-analysis

Subgroup

 

Sample size

Test of association

Test of heterogeneity

Test of publication bias (Begg’s test)

Test of publication bias (Egger’s test)

 

Genetic model

Case/Control

OR

95% CI (P-value)

OR

P

Z

P

T

P

Overall

Dominant

10,410 / 9406

2.15

1.84–2.50 (< 0.001)

38.3

0.002

1.49

0.13

1.64

0.11

Over-Dominant

10,410 / 9406

1.88

1.61–2.19 (< 0.001)

35.8

0.005

1.33

0.17

1.45

0.14

Allelic model

10,410 / 9406

2.05

1.79–2.35 (< 0.001)

48.6

≤0.001

1.45

0.16

1.59

0.13

GA vs. GG

10,410 / 9406

1.97

1.68–2.30 (< 0.001)

28.3

0.03

1.51

0.11

2.01

0.04

Iranian population

Dominant

1409 / 1160

3.04

2.04–4.54 (< 0.001)

37.3

0.13

−0.45

0.65

−0.53

0.61

Over-Dominant

1409 / 1160

2.65

1.74–4.05 (< 0.001)

0

0.66

−1.05

0.29

−0.64

0.55

Allelic model

1409 / 1160

2.09

0.88–4.94 (< 0.09)

76.8

0.008

−0.45

0.65

−0.33

0.75

GA vs. GG

1409 / 1160

2.67

1.81–4.22 (< 0.001)

0

0.59

−1.05

0.29

−0.67

0.53

Subgroup (continent)

Asia

Dominant

4153 / 3957

2.80

2.20–3.56(< 0.001)

35.4

0.06

−0.80

0.42

− 0.44

0.64

Over-Dominant

4153 / 3957

2.22

1.73–2.85 (< 0.001)

47.2

0.01

−1.43

0.15

−0.98

0.34

Allelic model

4153 / 3957

2.35

1.92–2.87 (< 0.001)

62.6

0.003

− 0.45

0.64

0.39

0.7

GA vs. GG

4153 / 3957

2.51

1.95–3.21 (< 0.001)

11.9

0.31

−1.10

0.27

−0.35

0.73

Europe

Dominant

4913 / 3929

1.49

1.20–1.84 (0.001)

14.7

0.25

3.06

0.002

3.79

0.001

Over-Dominant

4913 / 3929

1.43

1.15–1.79 (0.002)

16

0.23

2.99

0.003

3.65

0.001

Allelic model

4913 / 3929

1.48

1.19–1.81 (0.001)

9.9

0.32

1.37

0.16

1.58

0.13

GA vs. GG

4913 / 3929

1.44

1.15–1.80 (0.001)

16

0.23

2.96

0.003

3.65

0.001

South America

Dominant

761 / 1030

2.04

0.88–4.74 (0.09)

0

0.76

0.19

0.85

−0.53

0.62

Over-Dominant

761 / 1030

2.04

0.88–4.74 (0.09)

0

0.76

0.19

0.85

−0.53

0.62

Allelic model

761 / 1030

2

0.87–4.60 (0.1)

0

0.76

−0.19

0.85

−0.47

0.66

GA vs. GG

761 / 1030

2.04

0.88–4.74 (0.09)

0

0.76

0.19

0.85

−0.53

0.62

Africa

Dominant

438 / 389

5.65

3.15–10.14 (< 0.001)

3.9

0.37

1.36

0.17

2.55

0.12

Over-Dominant

438 / 389

4.44

2.45–8.03 (< 0.001)

3.2

0.37

1.36

0.17

2.41

0.13

Allelic model

438 / 389

5.93

3.38–10.40 (< 0.001)

0

0.55

1.36

0.17

2.59

0.12

GA vs. GG

438 / 389

4.70

2.59–8.53 (< 0.001)

12.3

0.33

1.36

0.17

2.47

0.13

Subgroup (Study design)

Case-Control

Dominant

8658 / 9099

2.33

1.99–2.74 (< 0.001)

31.5

0.01

0.28

0.78

0.79

0.43

Over-Dominant

8658 / 9099

2.05

1.74–2.41 (< 0.001)

29.3

0.02

1.43

0.15

1.28

0.21

Allelic model

8658 / 9099

2.18

1.8–2.52 (< 0.001)

44.9

0.003

0.71

0.47

0.87

0.39

GA vs. GG

8658 / 9099

2.16

1.83–2.55 (< 0.001)

18.2

0.13

1.70

0.09

1.78

0.08

Cohort

Dominant

1752 / 307

0.90

0.55–1.49 (0.68)

0

0.69

−1.23

0.47

−1.88

0.11

Over-Dominant

1752 / 307

0.88

0.54–1.46 (0.63)

0

0.64

−1.23

0.47

−0.95

0.38

Allelic model

1752 / 307

0.91

0.56–1.49 (0.71)

0

0.72

−1.23

0.47

− 1.27

0.25

GA vs. GG

1752 / 307

0.88

0.54–1.46 (0.63)

0

0.64

−1.23

0.47

−1.68

0.14