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Table 3 Main results of pooled ORs in meta-analysis of FVL 1691G > A mutation

From: Factor V Leiden 1691G > A mutation and the risk of recurrent pregnancy loss (RPL): systematic review and meta-analysis

Subgroup   Sample size Test of association Test of heterogeneity Test of publication bias (Begg’s test) Test of publication bias (Egger’s test)
  Genetic model Case/Control OR 95% CI (P-value) OR P Z P T P
Overall Dominant 10,410 / 9406 2.15 1.84–2.50 (< 0.001) 38.3 0.002 1.49 0.13 1.64 0.11
Over-Dominant 10,410 / 9406 1.88 1.61–2.19 (< 0.001) 35.8 0.005 1.33 0.17 1.45 0.14
Allelic model 10,410 / 9406 2.05 1.79–2.35 (< 0.001) 48.6 ≤0.001 1.45 0.16 1.59 0.13
GA vs. GG 10,410 / 9406 1.97 1.68–2.30 (< 0.001) 28.3 0.03 1.51 0.11 2.01 0.04
Iranian population Dominant 1409 / 1160 3.04 2.04–4.54 (< 0.001) 37.3 0.13 −0.45 0.65 −0.53 0.61
Over-Dominant 1409 / 1160 2.65 1.74–4.05 (< 0.001) 0 0.66 −1.05 0.29 −0.64 0.55
Allelic model 1409 / 1160 2.09 0.88–4.94 (< 0.09) 76.8 0.008 −0.45 0.65 −0.33 0.75
GA vs. GG 1409 / 1160 2.67 1.81–4.22 (< 0.001) 0 0.59 −1.05 0.29 −0.67 0.53
Subgroup (continent)
Asia Dominant 4153 / 3957 2.80 2.20–3.56(< 0.001) 35.4 0.06 −0.80 0.42 − 0.44 0.64
Over-Dominant 4153 / 3957 2.22 1.73–2.85 (< 0.001) 47.2 0.01 −1.43 0.15 −0.98 0.34
Allelic model 4153 / 3957 2.35 1.92–2.87 (< 0.001) 62.6 0.003 − 0.45 0.64 0.39 0.7
GA vs. GG 4153 / 3957 2.51 1.95–3.21 (< 0.001) 11.9 0.31 −1.10 0.27 −0.35 0.73
Europe Dominant 4913 / 3929 1.49 1.20–1.84 (0.001) 14.7 0.25 3.06 0.002 3.79 0.001
Over-Dominant 4913 / 3929 1.43 1.15–1.79 (0.002) 16 0.23 2.99 0.003 3.65 0.001
Allelic model 4913 / 3929 1.48 1.19–1.81 (0.001) 9.9 0.32 1.37 0.16 1.58 0.13
GA vs. GG 4913 / 3929 1.44 1.15–1.80 (0.001) 16 0.23 2.96 0.003 3.65 0.001
South America Dominant 761 / 1030 2.04 0.88–4.74 (0.09) 0 0.76 0.19 0.85 −0.53 0.62
Over-Dominant 761 / 1030 2.04 0.88–4.74 (0.09) 0 0.76 0.19 0.85 −0.53 0.62
Allelic model 761 / 1030 2 0.87–4.60 (0.1) 0 0.76 −0.19 0.85 −0.47 0.66
GA vs. GG 761 / 1030 2.04 0.88–4.74 (0.09) 0 0.76 0.19 0.85 −0.53 0.62
Africa Dominant 438 / 389 5.65 3.15–10.14 (< 0.001) 3.9 0.37 1.36 0.17 2.55 0.12
Over-Dominant 438 / 389 4.44 2.45–8.03 (< 0.001) 3.2 0.37 1.36 0.17 2.41 0.13
Allelic model 438 / 389 5.93 3.38–10.40 (< 0.001) 0 0.55 1.36 0.17 2.59 0.12
GA vs. GG 438 / 389 4.70 2.59–8.53 (< 0.001) 12.3 0.33 1.36 0.17 2.47 0.13
Subgroup (Study design)
Case-Control Dominant 8658 / 9099 2.33 1.99–2.74 (< 0.001) 31.5 0.01 0.28 0.78 0.79 0.43
Over-Dominant 8658 / 9099 2.05 1.74–2.41 (< 0.001) 29.3 0.02 1.43 0.15 1.28 0.21
Allelic model 8658 / 9099 2.18 1.8–2.52 (< 0.001) 44.9 0.003 0.71 0.47 0.87 0.39
GA vs. GG 8658 / 9099 2.16 1.83–2.55 (< 0.001) 18.2 0.13 1.70 0.09 1.78 0.08
Cohort Dominant 1752 / 307 0.90 0.55–1.49 (0.68) 0 0.69 −1.23 0.47 −1.88 0.11
Over-Dominant 1752 / 307 0.88 0.54–1.46 (0.63) 0 0.64 −1.23 0.47 −0.95 0.38
Allelic model 1752 / 307 0.91 0.56–1.49 (0.71) 0 0.72 −1.23 0.47 − 1.27 0.25
GA vs. GG 1752 / 307 0.88 0.54–1.46 (0.63) 0 0.64 −1.23 0.47 −1.68 0.14
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