Subgroup |  | Sample size | Test of association | Test of heterogeneity | Test of publication bias (Begg’s test) | Test of publication bias (Egger’s test) | ||||
 | Genetic model | Case/Control | OR | 95% CI (P-value) | OR | P | Z | P | T | P |
Overall | Dominant | 10,410 / 9406 | 2.15 | 1.84–2.50 (< 0.001) | 38.3 | 0.002 | 1.49 | 0.13 | 1.64 | 0.11 |
Over-Dominant | 10,410 / 9406 | 1.88 | 1.61–2.19 (< 0.001) | 35.8 | 0.005 | 1.33 | 0.17 | 1.45 | 0.14 | |
Allelic model | 10,410 / 9406 | 2.05 | 1.79–2.35 (< 0.001) | 48.6 | ≤0.001 | 1.45 | 0.16 | 1.59 | 0.13 | |
GA vs. GG | 10,410 / 9406 | 1.97 | 1.68–2.30 (< 0.001) | 28.3 | 0.03 | 1.51 | 0.11 | 2.01 | 0.04 | |
Iranian population | Dominant | 1409 / 1160 | 3.04 | 2.04–4.54 (< 0.001) | 37.3 | 0.13 | −0.45 | 0.65 | −0.53 | 0.61 |
Over-Dominant | 1409 / 1160 | 2.65 | 1.74–4.05 (< 0.001) | 0 | 0.66 | −1.05 | 0.29 | −0.64 | 0.55 | |
Allelic model | 1409 / 1160 | 2.09 | 0.88–4.94 (< 0.09) | 76.8 | 0.008 | −0.45 | 0.65 | −0.33 | 0.75 | |
GA vs. GG | 1409 / 1160 | 2.67 | 1.81–4.22 (< 0.001) | 0 | 0.59 | −1.05 | 0.29 | −0.67 | 0.53 | |
Subgroup (continent) | ||||||||||
Asia | Dominant | 4153 / 3957 | 2.80 | 2.20–3.56(< 0.001) | 35.4 | 0.06 | −0.80 | 0.42 | − 0.44 | 0.64 |
Over-Dominant | 4153 / 3957 | 2.22 | 1.73–2.85 (< 0.001) | 47.2 | 0.01 | −1.43 | 0.15 | −0.98 | 0.34 | |
Allelic model | 4153 / 3957 | 2.35 | 1.92–2.87 (< 0.001) | 62.6 | 0.003 | − 0.45 | 0.64 | 0.39 | 0.7 | |
GA vs. GG | 4153 / 3957 | 2.51 | 1.95–3.21 (< 0.001) | 11.9 | 0.31 | −1.10 | 0.27 | −0.35 | 0.73 | |
Europe | Dominant | 4913 / 3929 | 1.49 | 1.20–1.84 (0.001) | 14.7 | 0.25 | 3.06 | 0.002 | 3.79 | 0.001 |
Over-Dominant | 4913 / 3929 | 1.43 | 1.15–1.79 (0.002) | 16 | 0.23 | 2.99 | 0.003 | 3.65 | 0.001 | |
Allelic model | 4913 / 3929 | 1.48 | 1.19–1.81 (0.001) | 9.9 | 0.32 | 1.37 | 0.16 | 1.58 | 0.13 | |
GA vs. GG | 4913 / 3929 | 1.44 | 1.15–1.80 (0.001) | 16 | 0.23 | 2.96 | 0.003 | 3.65 | 0.001 | |
South America | Dominant | 761 / 1030 | 2.04 | 0.88–4.74 (0.09) | 0 | 0.76 | 0.19 | 0.85 | −0.53 | 0.62 |
Over-Dominant | 761 / 1030 | 2.04 | 0.88–4.74 (0.09) | 0 | 0.76 | 0.19 | 0.85 | −0.53 | 0.62 | |
Allelic model | 761 / 1030 | 2 | 0.87–4.60 (0.1) | 0 | 0.76 | −0.19 | 0.85 | −0.47 | 0.66 | |
GA vs. GG | 761 / 1030 | 2.04 | 0.88–4.74 (0.09) | 0 | 0.76 | 0.19 | 0.85 | −0.53 | 0.62 | |
Africa | Dominant | 438 / 389 | 5.65 | 3.15–10.14 (< 0.001) | 3.9 | 0.37 | 1.36 | 0.17 | 2.55 | 0.12 |
Over-Dominant | 438 / 389 | 4.44 | 2.45–8.03 (< 0.001) | 3.2 | 0.37 | 1.36 | 0.17 | 2.41 | 0.13 | |
Allelic model | 438 / 389 | 5.93 | 3.38–10.40 (< 0.001) | 0 | 0.55 | 1.36 | 0.17 | 2.59 | 0.12 | |
GA vs. GG | 438 / 389 | 4.70 | 2.59–8.53 (< 0.001) | 12.3 | 0.33 | 1.36 | 0.17 | 2.47 | 0.13 | |
Subgroup (Study design) | ||||||||||
Case-Control | Dominant | 8658 / 9099 | 2.33 | 1.99–2.74 (< 0.001) | 31.5 | 0.01 | 0.28 | 0.78 | 0.79 | 0.43 |
Over-Dominant | 8658 / 9099 | 2.05 | 1.74–2.41 (< 0.001) | 29.3 | 0.02 | 1.43 | 0.15 | 1.28 | 0.21 | |
Allelic model | 8658 / 9099 | 2.18 | 1.8–2.52 (< 0.001) | 44.9 | 0.003 | 0.71 | 0.47 | 0.87 | 0.39 | |
GA vs. GG | 8658 / 9099 | 2.16 | 1.83–2.55 (< 0.001) | 18.2 | 0.13 | 1.70 | 0.09 | 1.78 | 0.08 | |
Cohort | Dominant | 1752 / 307 | 0.90 | 0.55–1.49 (0.68) | 0 | 0.69 | −1.23 | 0.47 | −1.88 | 0.11 |
Over-Dominant | 1752 / 307 | 0.88 | 0.54–1.46 (0.63) | 0 | 0.64 | −1.23 | 0.47 | −0.95 | 0.38 | |
Allelic model | 1752 / 307 | 0.91 | 0.56–1.49 (0.71) | 0 | 0.72 | −1.23 | 0.47 | − 1.27 | 0.25 | |
GA vs. GG | 1752 / 307 | 0.88 | 0.54–1.46 (0.63) | 0 | 0.64 | −1.23 | 0.47 | −1.68 | 0.14 |