Microthrombosis | Fibrin clot disease | Macrothrombosis | |
---|---|---|---|
Level of vascular injury | ECs (Level 1) | EVT (Level 2 only) | ECs/SET/EVT (Combined Level 3) |
Activated path | ULVWF or aberrant ULVWF path | TF or aberrant TF path | Combined ULVWF & TF path |
Mechanism | Microthrombogenesis | Fibrinogenesis | Macrothrombogenesis |
Participants | ULVWF Platelet | TF Coagulation factors | ULVWF-platelet complexes Fibrin meshes NETs |
Character of thrombi | Microthrombi | Fibrin clots | Macrothrombus |
Examples of disease | VMTD Generalized: EA-VMTD (e.g., TTP-like syndrome, including false DIC) AA-VMTD* GA-VMTD* Local: Kasabach-Merritt syndrome Focal: TIA; HERNS syndrome | Hemorrhagic stroke: SDH Hemarthrosis APL-associated coagulopathy* | DVT PE Myocardial infarction Acute ischemic stroke Gangrene |