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Table 1 The characteristics of included studies in this meta-analysis

From: GST null polymorphisms may affect the risk of coronary artery disease: evidence from a meta-analysis

First author, year Country Ethnicity Type of disease Sample size
Case/Control
Null genotype [n(%)] NOS score
Cases Controls
GSTM1 null
 Abu-Amero 2006 Saudi Arabia Mixed Coronary artery disease (CAD) 1054/762 655 (62.1%) 117 (15.3%) 7
 Bazo 2011 Brazil Mixed Coronary artery disease (CAD) 297/96 160 (53.8%) 40 (41.7%) 7
 Bhat 2016 India Mixed Coronary artery disease (CAD) 200/200 62 (31.0%) 36 (18.0%) 8
 Bhatti 2018 India Mixed Coronary artery disease (CAD) 562/564 217 (38.6%) 127 (22.5%) 7
 Cora 2013 Turkey Caucasian Myocardial infarction (MI) 324/296 182 (56.1%) 143 (48.3%) 8
 Cornelis 2007 Canada Caucasian Myocardial infarction (MI) 2042/2042 980 (48.0%) 1041 (51.0%) 7
 Evans 1996 Saudi Arabia Mixed Coronary artery disease (CAD) 90/884 57 (63.3%) 484 (54.8%) 7
 Girisha 2004 India Mixed Coronary artery disease (CAD) 197/198 46 (23.4%) 41 (20.7%) 7
 Hayek 2006 Israel Mixed Coronary artery disease (CAD) 193/2399 88 (45.6%) 1142 (47.6%) 8
 Kadıoğlu 2016 Turkey Caucasian Coronary artery disease (CAD) 29/30 17 (58.6%) 14 (46.7%) 7
 Kariž 2012 Slovenia Caucasian Myocardial infarction (MI) 206/257 142 (69.0%) 166 (64.6%) 7
 Kim 2008 Korea East Asian Coronary artery disease (CAD) 356/336 198 (55.6%) 191 (56.8%) 7
 Li 2000 USA Mixed Coronary artery disease (CAD) 400/790 178 (44.5%) 354 (44.8%) 7
 Macie 2009 Brazil Mixed Coronary artery disease (CAD) 869/1573 557 (64.1%) 789 (50.2%) 7
 Manfredi 2007 Italy Caucasian Coronary artery disease (CAD) 169/53 99 (58.6%) 24 (45.3%) 7
 Manfredi 2009 Italy Caucasian Coronary artery disease (CAD) 184/47 108 (58.7%) 18 (38.3%) 7
 Martin 2009 USA Mixed Coronary artery disease (CAD) 67/63 41 (61.2%) 19 (30.2%) 7
 Masetti 2003 Italy Caucasian Coronary artery disease (CAD) 308/122 163 (52.9%) 66 (54.1%) 8
 Mir 2016 India Mixed Coronary artery disease (CAD) 100/100 42 (42.0%) 26 (26.0%) 8
 Nomani 2011 Iran Mixed Coronary artery disease (CAD) 209/108 100 (47.8%) 57 (52.8%) 8
 Norskov 2011 Denmark Caucasian Coronary artery disease (CAD) 4930/21684 2052 (41.6%) 11,362 (52.4%) 7
 Olshan 2003 USA Mixed Coronary artery disease (CAD) 526/868 252 (47.9%) 352 (40.6%) 8
 Pašalić 2017 Croatia Caucasian Coronary artery disease (CAD) 71/174 29 (40.8%) 69 (39.7%) 7
 Phulukdaree 2012 India Mixed Coronary artery disease (CAD) 102/100 37 (36.3%) 18 (18.0%) 7
 Pourkeramati 2020 Iran Mixed Coronary artery disease (CAD) 244/281 128 (52.5%) 138 (49.1%) 8
 Ramprasath 2011 India Mixed Coronary artery disease (CAD) 290/270 128 (44.1%) 56 (20.7%) 7
 Salama 2002 USA Mixed Coronary artery disease (CAD) 130/90 45 (34.6%) 33 (36.7%) 7
 Singh 2011 India Mixed Myocardial infarction (MI) 230/300 56 (24.3%) 65 (21.7%) 8
 Tamer 2004 Turkey Caucasian Coronary artery disease (CAD) 148/247 67 (45.3%) 103 (41.7%) 7
 Tang 2009 China East Asian Coronary artery disease (CAD) 277/277 89 (32,.1%) 59 (21.3%) 7
 Taspinar 2012 Turkey Caucasian Coronary artery disease (CAD) 122/142 51 (41.8%) 66 (46.5%) 7
 Wang 2002 Australia Caucasian Coronary artery disease (CAD) 612/256 343 (56.0%) 153 (59.8%) 7
 Wang 2008 China East Asian Coronary artery disease (CAD) 277/277 89 (32.1%) 59 (21.3%) 8
 Wilson 2000 UK Caucasian Myocardial infarction (MI) 356/187 191 (53.7%) 107 (57.2%) 8
 Wilson 2003 UK Mixed Coronary artery disease (CAD) 170/203 70 (41.2%) 107 (52.7%) 7
 Yeh 2013 Taiwan East Asian Coronary artery disease (CAD) 458/209 253 (55.2%) 121 (57.9%) 8
 Zhang 2011 China East Asian Coronary artery disease (CAD) 255/145 120 (47.1%) 46 (31.7%) 7
GSTP1 null
 Bhat 2016 India Mixed Coronary artery disease (CAD) 200/200 132 (66.0%) 104 (52.0%) 8
 Bhatti 2018 India Mixed Coronary artery disease (CAD) 560/545 366 (65.4%) 307 (56.3%) 7
 Cornelis 2007 Canada Caucasian Myocardial infarction (MI) 2042/2042 817 (40.0%) 817 (40.0%) 7
 Kariž 2012 Slovenia Caucasian Myocardial infarction (MI) 206/257 135 (65.5%) 140 (54.5%) 7
 Kovacs 2014 Hungary Caucasian Myocardial infarction (MI) 54/78 27 (50.0%) 26 (33.3%) 7
 Nomani 2011 Iran Mixed Coronary artery disease (CAD) 209/108 118 (56.4%) 60 (55.5%) 8
 Phulukdaree 2012 India Mixed Coronary artery disease (CAD) 102/100 36 (35.3%) 52 (52.0%) 7
 Pourkeramati 2020 Iran Mixed Coronary artery disease (CAD) 244/281 64 (26.2%) 56 (19.9%) 8
 Ramprasath 2011 India Mixed Coronary artery disease (CAD) 290/270 196 (67.6%) 152 (56.3%) 7
 Singh 2011 India Mixed Myocardial infarction (MI) 230/300 90 (39.1%) 117 (39.0%) 8
 Yeh 2013 Taiwan East Asian Coronary artery disease (CAD) 458/209 125 (27.3%) 59 (28.2%) 8
GSTT1 null
 Abu-Amero 2006 Saudi Arabia Mixed Coronary artery disease (CAD) 1054/762 463 (43.9%) 66 (8.7%) 7
 Bazo 2011 Brazil Mixed Coronary artery disease (CAD) 297/100 69 (23.2%) 19 (19.0%) 7
 Bhat 2016 India Mixed Coronary artery disease (CAD) 200/200 12 (6.0%) 25 (12.5%) 8
 Bhatti 2018 India Mixed Coronary artery disease (CAD) 562/564 86 (15.3%) 129 (22.9%) 7
 Cora 2013 Turkey Caucasian Myocardial infarction (MI) 324/296 106 (32.7%) 63 (21.3%) 8
 Cornelis 2007 Canada Caucasian Myocardial infarction (MI) 2042/2042 388 (19.0%) 408 (20.0%) 7
 Decharatchakul 2020 Thailand East Asian Coronary artery disease (CAD) 279/735 115 (41.9%) 242 (32.9%) 8
 García 2018 Mexico Mixed Coronary artery disease (CAD) 79/101 15 (19.0%) 8 (7.9%) 7
 Girisha 2004 India Mixed Coronary artery disease (CAD) 197/198 15 (7.6%) 36 (18.2%) 7
 Hayek 2006 Israel Mixed Coronary artery disease (CAD) 193/2399 30 (15.5%) 392 (16.3%) 8
 Kadıoğlu 2016 Turkey Caucasian Coronary artery disease (CAD) 29/30 6 (20.7%) 5 (16.7%) 7
 Kariž 2012 Slovenia Caucasian Myocardial infarction (MI) 206/257 77 (37.4%) 108 (42.0%) 7
 Kim 2008 Korea East Asian Coronary artery disease (CAD) 356/336 196 (55.0%) 187 (55.7%) 7
 Li 2000 USA Mixed Coronary artery disease (CAD) 400/890 74 (18.5%) 166 (18.7%) 7
 Lakshmi 2012 India Mixed Coronary artery disease (CAD) 352/282 81 (23.0%) 39 (13.8%) 7
 Levinsson 2014 Sweden Caucasian Coronary artery disease (CAD) 112/1221 11 (9.8%) 168 (13.8) 7
 Macie 2009 Brazil Mixed Coronary artery disease (CAD) 869/1573 209 (24.1%) 337 (21.4%) 7
 Manfredi 2007 Italy Caucasian Coronary artery disease (CAD) 169/53 95 (56.2%) 13 (24.5%) 7
 Manfredi 2009 Italy Caucasian Coronary artery disease (CAD) 184/47 84 (45.7%) 13 (27.7%) 7
 Martin 2009 USA Mixed Coronary artery disease (CAD) 67/63 12 (17.9%) 12 (19.7%) 7
 Masetti 2003 Italy Caucasian Coronary artery disease (CAD) 308/122 117 (38.0%) 40 (32.8%) 8
 Mir 2016 India Mixed Coronary artery disease (CAD) 100/100 23 (23.0%) 16 (16.0%) 8
 Nomani 2011 Iran Mixed Coronary artery disease (CAD) 209/108 16 (7.7%) 17 (15.7%) 8
 Norskov 2011 Denmark Caucasian Coronary artery disease (CAD) 4930/21684 740 (15.0%) 3161 (14.6%) 7
 Olshan 2003 USA Mixed Coronary artery disease (CAD) 526/868 75 (14.3%) 165 (19.0%) 8
 Palmer 2003 UK Caucasian Coronary artery disease (CAD) 51/57 40 (78.4%) 35 (61.4%) 7
 Pašalić 2017 Croatia Caucasian Coronary artery disease (CAD) 68/177 17 (25.0%) 54 (30.5%) 7
 Pourkeramati 2020 Iran Mixed Coronary artery disease (CAD) 244/281 129 (52.9%) 143 (50.8%) 8
 Ramprasath 2011 India Mixed Coronary artery disease (CAD) 290/492 136 (46.9%) 118 (24.0%) 7
 Salama 2002 USA Mixed Coronary artery disease (CAD) 130/90 32 (26.7%) 14 (15.6%) 7
 Singh 2011 India Mixed Myocardial infarction (MI) 230/300 23 (10.0%) 61 (20.3%) 8
 Tamer 2004 Turkey Caucasian Coronary artery disease (CAD) 148/247 48 (32.4%) 70 (28.3%) 7
 Tang 2009 China East Asian Coronary artery disease (CAD) 277/277 77 (27.8%) 53 (19.1%) 7
 Taspinar 2012 Turkey Caucasian Coronary artery disease (CAD) 122/142 28 (23.0%) 25 (17.6%) 7
 Wang 2008 China East Asian Coronary artery disease (CAD) 277/277 77 (27.8%) 53 (19.1%) 8
 Wilson 2000 UK Caucasian Myocardial infarction (MI) 356/187 90 (25.3%) 36 (19.3%) 8
 Wilson 2003 UK Mixed Coronary artery disease (CAD) 170/203 34 (20.0%) 44 (21.7%) 7
 Yeh 2013 Taiwan East Asian Coronary artery disease (CAD) 458/209 276 (60.3%) 110 (52.6%) 8
 Zhang 2011 China East Asian Coronary artery disease (CAD) 255/145 141 (55.3%) 60 (41.4%) 7
  1. Abbreviations: HWE Hardy-Weinberg equilibrium, NOS Newcastle-Ottawa scale, NA Not available