Table 2 Integrated analyses for GST null polymorphisms and CAD
From: GST null polymorphisms may affect the risk of coronary artery disease: evidence from a meta-analysis
Polymorphisms | Population | Sample size (Cases/controls) | Null genotype vs. Present genotype | ||
|---|---|---|---|---|---|
P value | OR (95%CI) | I2 statistic | |||
GSTM1 null | CAD | 17,054/36630 | 0.003 | 1.37 (1.11-1.70) | 95% |
Caucasian | 9501/25537 | 0.72 | 1.04 (0.85-1.26) | 84% | |
East Asian | 1623/1244 | 0.07 | 1.35 (0.97-1.88) | 76% | |
Mixed population | 5930/9849 | 0.004 | 1.61 (1.16-2.22) | 94% | |
GSTP1 null | CAD | 4595/4390 | 0.03 | 1.23 (1.02-1.48) | 70% |
Caucasian | 2302/2377 | 0.17 | 1.35 (0.88-2.07) | 76% | |
Mixed population | 1835/1804 | 0.11 | 1.23 (0.96-1.59) | 68% | |
GSTT1 null | CAD | 17,120/38115 | 0.02 | 1.23 (1.03-1.46) | 89% |
Caucasian | 9049/26562 | 0.02 | 1.23 (1.03-1.47) | 67% | |
East Asian | 1902/1979 | < 0.0001 | 1.38 (1.20-1.59) | 36% | |
Mixed population | 6169/9574 | 0.61 | 1.11 (0.76-1.62) | 94% | |