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Table 2 Patients’ hemostatic values before platelet transfusion

From: A modified microchip-based flow chamber system for evaluating thrombogenicity in patients with thrombocytopenia

Hemostatic parameter

Major bleeding group (mean ± SD)

Minor bleeding group (mean ± SD)

P

General tests

Platelet (103/μL)

27.2 ± 18.2

39.8 ± 11.6

0.259

PT-INR

1.4 ± 0.5

1.5 ± 0.5

0.733

PT (sec)

16.3 ± 5.3

17.8 ± 5.7

0.676

APTT (sec)

71.2 ± 28.7

74.8 ± 41.0

0.872

Fibrinogen (mg/dl)

414.5 ± 343.0

385.8 ± 439.9

0.910

ROTEM

EXTEM clotting time (sec)

94.5 ± 18.7

64.5 ± 13.4

0.025

EXTEM MCF (mm)

41.0 ± 5.7

44.3 ± 12.4

0.583

INTEM clotting time (sec)

299.2 ± 85.9

284.3 ± 55.3

0.768

INTEM MCF (mm)

39.5 ± 4.4

40.8 ± 12.6

0.824

Multiplate

Collagen-induced aggregation (U)

67.5 ± 51.6

100.5 ± 23.0

0.270

ADP-induced aggregation (U)

19.3 ± 17.2

42.0 ± 17.7

0.078

TRAP-induced aggregation (U)

44.3 ± 46.2

69.8 ± 23.2

0.344

Ristocetin-induced aggregation (U)

8.7 ± 8.4

5.0 ± 3.4

0.439

T-TAS

Occlusion time (min)

>  30

16.3 ± 3.3

<  0.01

AUC

171.5 ± 305.3

1291.2 ± 298.7

<  0.01

  1. SD standard deviation; PT prothrombin time; INR international normalized ratio; APTT activated partial thromboplastin time; MCF maximum clot firmness; ADP adenosine diphosphate; TRAP thrombin receptor activating peptide; AUC area under the curve