Fig. 6

Higher thrombin generation response in vitro in plasma collected 1–2 h after FXIa administration. a Thrombin peak height in terminal mouse plasma (collected at the conclusion of the FeCl₃ experiments), paired experiments performed with and without antibody for FXIa. In the absence of the antibody, animals that received npIG+FXIa have significantly higher thrombin generation in vitro compared to those that did not receive FXIa (untreated and treated with npIG). The addition of the antibody for FXIa significantly reduced thrombin generation in the former, but not in the latter, suggesting FXIa-dependent procoagulant activity that persists for the duration of the study. b Absolute difference in thrombin peak height in terminal mouse plasma following the addition of anti-FXIa antibody. For each animal the difference in respective thrombin peaks before and after adding anti-FXIa antibody is calculated.*, significant difference, unpaired 2 sample t-test, Bonferroni correction for multiple comparisons; **, significant difference, paired t-test