The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes

Table 2 Correlations (r) of participant characteristics with total and γ’ fibrinogen concentrations and clot properties

Participant’s characteristics (Whole group)		Total fibrinogen	% fibrinogen γ’	Lag time	Slope	Maximum absorbance	CLT
Age (yr)		0.16**	−0.11***	0.13***	0.11***	0.15***	−0.003
PA index		0.01	− 0.06*	− 0.20***	0.17***	− 0.06*	0.04
BMI (kg/m²)		0.16***	0.06*	−0.006	0.03	0.12***	0.48**
Waist circumference (cm)		0.14***	0.06*	−0.004	0.02	0.10***	0.42**
Biochemical markers	TC (mmol/L)	0.08***	−0.07**	0.03	0.03	0.06*	0.09***
	LDL-C (mmol/L)	0.13***	−0.03	0.03	0.06**	0.09***	0.16***
	HDL-C (mmol/L)	−0.08***	− 0.13***	0.04	0.03	−0.01	− 0.19***
	Triglycerides (mmol/L)	0.07**	0.03	−0.03	−0.07**	0.004	0.20***
	HbA1c (%)	0.20***	0.008	0.008	0.07**	0.12***	0.20***
	CRP (mg/L)	0.42***	−0.07**	0.04	0.22***	0.42**	0.23***
	GGT (U/l)	−0.10***	− 0.01	0.005; − 0.03	−0.07**; − 0.01	−0.09**; − 0.05	−0.15*; − 0.19* − 0.134***
	%CDT	− 0.09***	− 0.01	0.006; − 0.009	0.03; 0.09**	− 0.04; 0.02	− 0.14*; − 0.25* − 0.111***
	GGT-CDT	− 0.14***	− 0.007	− 0.02; − 0.02	− 0.04; 0.03	− 0.13***; − 0.04	− 0.30*; − 0.28* − 0.162***
	ALT (IU/L)	− 0.11***	0.02	−0.03; − 0.02	−0.11*; − 0.07	− 0.14*; − 0.10*	−0.01*; − 0.07 − 0.048*
	AST (IU/L)	−0.22***	0.11***	−0.04*; − 0.03	−0.12**; − 0.04	−0.18**; − 0.01	−0.24*; − 0.21* − 0.107***
Alcohol intake (g/day)^a		−0.09**	− 0.08*	− 0.06; − 0.05*	0.04; 0.03	− 0.08; − 0.05	−0.18*; − 0.24 − 0.145***

ALT Alanine transaminase, AST Aspartate aminotransferase, BMI Body mass index, CLT Clot lysis time, CRP High sensitivity C-reactive protein, %CDT Percentage carbohydrate deficient transferrin, GGT Gamma-glutamyltransferase, GGT-CDT 0.8 x ln(GGT) + 1.3 x ln(%CDT), HbA1c Glycosylated haemoglobin A1c, HDL-c High-density lipoprotein cholesterol, LDL-c Low-density lipoprotein cholesterol, n Number of patients, PA Physical activity, r Correlation coefficient, TC Total cholesterol
First r-value is for Spearman correlation; second for Spearman partial correlations of alcohol markers with clot properties adjusting for fibrinogen to determine how alcohol associates with clot properties independent of fibrinogen concentrations; third r-value for Spearman partial correlations of alcohol markers with CLT adjusting for fibrinogen, HbA1c and BMI to determine how alcohol associates with CLT independent of fibrinogen concentrations as well as HbA1c and BMI
*p < 0.05; **p ≤ 0.01; ***p ≤ 0.001; ^aonly consumers included

ISSN: 1477-9560