The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes

Rautenbach, Petro Hannie; Nienaber-Rousseau, Cornelie; Pieters, Marlien

doi:10.1186/s12959-020-00249-4

Table 3 Correlations (r) stratified for drinkers and abstainers

From: The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes

Participant characteristics		Total fibrinogen		%fibrinogen γ’		Lag time		Slope		Maximum absorbance		CLT
Participant characteristics		Drinkers	Abstainers	Drinkers	Abstainers	Drinkers	Abstainers	Drinkers	Abstainers	Drinkers	Abstainers	Drinkers	Abstainers
Age (yr)		0.19***	0.15***	−0.14***	−0.11***	0.05	0.05*	0.15***	0.11***	0.19***	0.18***	−0.12***	0.02
PA index		−0.02	0.004	−0.02	− 0.05*	− 0.24***	− 0.20***	0.20***	0.17***	−0.04	− 0.07**	0.04	0.03
BMI (kg/m²)		0.09*	0.17***	0.10**	0.05*	−0.05	− 0.03	− 0.03	0.03	0.05	0.15***	0.48**	0.48**
Waist circumference (cm)		0.06	0.14***	0.08*	0.06*	−0.08*	− 0.04	− 0.006	0.02	0.03	0.11***	0.40***	0.43**
Biochemical markers	TC (mmol/L)	0.06	0.07**	− 0.11**	− 0.07**	− 0.02	0.006	0.05	0.03	0.07*	0.10***	0.11**	0.16***
	LDL-C (mmol/L)	0.08*	0.12***	−0.02	− 0.03	0.02	0.03	0.06	0.06*	0.10**	0.14***	0.25***	0.28**
	HDL-C (mmol/L)	−0.01	− 0.09***	− 0.23***	− 0.12***	− 0.01	0.03	0.10**	0.03	0.03	− 0.01	− 0.36***	− 0.31**
	Triglycerides (mmol/L)	0.02	0.07**	0.06	0.03	−0.09*	− 0.08***	− 0.09*	−0.07**	− 0.04	−0.005	0.35***	0.33**
	HbA1c (%)	0.17***	0.20***	0.002	0.007	0.03	− 0.02	0.05	0.08**	0.18***	0.18***	0.28***	0.35**
	CRP (mg/L)	0.39***	0.42**	−0.06	− 0.06*	0.01	0.04	0.23***	0.22***	0.40**	0.42**	0.20***	0.23***
	GGT (U/l)	−0.15***	−0.11***	− 0.03	− 0.004	− 0.07*; − 0.07	−0.03; − 0.01	−0.05; 0.04	− 0.07**; − 0.03	−0.20*; − 0.11	−0.11***; 0.04	− 0.23*; − 0.21* − 0,182***	−0.21***; 0.01 − 0,021
	%CDT	−0.02	− 0.10***	− 0.10**	− 0.01	0.02; 0.02	− 0.01; − 0.05	0.06; 0.07	0.03; 0.13***	0.005; 0.05	− 0.06*; 0.02	− 0.27*; − 0.29* − 0,179***	−0.26**; − 0.09 − 0,001
	GGT-CDT	−0.13***	− 0.15***	− 0.08*	− 0.001	− 0.03; − 0.02	− 0.02; − 0.05	−0.009; 0.06	− 0.04; 0.07	−0.15***; − 0.05	−0.13***; 0.03	− 0.34*; − 0.33* − 0,249***	−0.31**; − 0.07 − 0,026
	ALT (IU/L)	− 0.14***	− 0.12***	0.01	0.02	−0.06; − 0.05	−0.02; 0.013	− 0.07*; − 0.00	−0.12*; − 0.13*	−0.20*; − 0.11	−0.14***; − 0.05	−0.11*; − 0.09 − 0,097*	−0.10***; 0.028 0,01
	AST (IU/L)	−0.21***	−0.23***	0.06	0.11***	−0.06; − 0.04	−0.04; − 0.04	−0.08*; − 0.01	−0.12***; − 0.06	−0.21**; − 0.1	−0.18***; − 0.02	−0.25*; − 0.22* − 0,15***	−0.24*; − 0.094 − 0,038
Alcohol intake (g/day)		−0.09**	–	− 0.08*	–	−0.06; − 0.04	–	0.04; 0.08*	–	−0.08*; − 0.02	–	− 0.18*; − 0.19* − 0,137***	–

First r-value is for Spearman correlation; second r-value for Spearman partial correlations of alcohol markers with clot properties adjusting for fibrinogen to determine how alcohol associates with clot properties independent of fibrinogen concentrations; third r-value for Spearman partial correlations of alcohol markers with CLT adjusting for fibrinogen, HbA1c and BMI to determine how alcohol associates with CLT independent of fibrinogen concentrations as well as HbA1c and BMI
*p < 0.05; **p ≤ 0.01; ***p ≤ 0.001
ALT Alanine transaminase, AST Aspartate aminotransferase, BMI Body mass index, CLT Clot lysis time, CRP High sensitivity C-reactive protein, %CDT Percentage carbohydrate deficient transferrin, GGT Gamma-glutamyltransferase, GGT-CDT 0.8 x ln(GGT) + 1.3 x ln(%CDT), HbA1c Glycosylated haemoglobin A1c, HDL-c High-density lipoprotein cholesterol, LDL-c Low-density lipoprotein cholesterol, n Number of patients, PA Physical activity, r Correlation coefficient; TC Total cholesterol

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