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Table 3 Correlations (r) stratified for drinkers and abstainers

From: The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes

Participant characteristics Total fibrinogen %fibrinogen γ’ Lag time Slope Maximum absorbance CLT
Drinkers Abstainers Drinkers Abstainers Drinkers Abstainers Drinkers Abstainers Drinkers Abstainers Drinkers Abstainers
Age (yr) 0.19*** 0.15*** −0.14*** −0.11*** 0.05 0.05* 0.15*** 0.11*** 0.19*** 0.18*** −0.12*** 0.02
PA index −0.02 0.004 −0.02 − 0.05* − 0.24*** − 0.20*** 0.20*** 0.17*** −0.04 − 0.07** 0.04 0.03
BMI (kg/m2) 0.09* 0.17*** 0.10** 0.05* −0.05 − 0.03 − 0.03 0.03 0.05 0.15*** 0.48** 0.48**
Waist circumference (cm) 0.06 0.14*** 0.08* 0.06* −0.08* − 0.04 − 0.006 0.02 0.03 0.11*** 0.40*** 0.43**
Biochemical markers TC (mmol/L) 0.06 0.07** − 0.11** − 0.07** − 0.02 0.006 0.05 0.03 0.07* 0.10*** 0.11** 0.16***
LDL-C (mmol/L) 0.08* 0.12*** −0.02 − 0.03 0.02 0.03 0.06 0.06* 0.10** 0.14*** 0.25*** 0.28**
HDL-C (mmol/L) −0.01 − 0.09*** − 0.23*** − 0.12*** − 0.01 0.03 0.10** 0.03 0.03 − 0.01 − 0.36*** − 0.31**
Triglycerides (mmol/L) 0.02 0.07** 0.06 0.03 −0.09* − 0.08*** − 0.09* −0.07** − 0.04 −0.005 0.35*** 0.33**
HbA1c (%) 0.17*** 0.20*** 0.002 0.007 0.03 − 0.02 0.05 0.08** 0.18*** 0.18*** 0.28*** 0.35**
CRP (mg/L) 0.39*** 0.42** −0.06 − 0.06* 0.01 0.04 0.23*** 0.22*** 0.40** 0.42** 0.20*** 0.23***
GGT (U/l) −0.15*** −0.11*** − 0.03 − 0.004 − 0.07*;
− 0.07
−0.03;
− 0.01
−0.05;
0.04
− 0.07**;
− 0.03
−0.20***;
− 0.11**
−0.11***; 0.04 − 0.23***;
− 0.21***
− 0,182***
−0.21***;
0.01
− 0,021
%CDT −0.02 − 0.10*** − 0.10** − 0.01 0.02;
0.02
− 0.01;
− 0.05
0.06;
0.07
0.03;
0.13***
0.005;
0.05
− 0.06*; 0.02 − 0.27***;
− 0.29***
− 0,179***
−0.26***;
− 0.09*
− 0,001
GGT-CDT −0.13*** − 0.15*** − 0.08* − 0.001 − 0.03;
− 0.02
− 0.02;
− 0.05
−0.009;
0.06
− 0.04;
0.07
−0.15***;
− 0.05
−0.13***; 0.03 − 0.34***;
− 0.33***
− 0,249***
−0.31**;
− 0.07
− 0,026
ALT (IU/L) − 0.14*** − 0.12*** 0.01 0.02 −0.06;
− 0.05
−0.02;
0.013
− 0.07*;
− 0.00
−0.12***;
− 0.13***
−0.20***;
− 0.11**
−0.14***; − 0.05 −0.11**;
− 0.09*
− 0,097*
−0.10***;
0.028
0,01
AST (IU/L) −0.21*** −0.23*** 0.06 0.11*** −0.06;
− 0.04
−0.04;
− 0.04
−0.08*;
− 0.01
−0.12***;
− 0.06
−0.21***;
− 0.1*
−0.18***; − 0.02 −0.25***;
− 0.22***
− 0,15***
−0.24***;
− 0.094**
− 0,038
Alcohol intake (g/day) −0.09** − 0.08* −0.06;
− 0.04
0.04;
0.08*
−0.08*;
− 0.02
− 0.18***;
− 0.19***
− 0,137***
  1. First r-value is for Spearman correlation; second r-value for Spearman partial correlations of alcohol markers with clot properties adjusting for fibrinogen to determine how alcohol associates with clot properties independent of fibrinogen concentrations; third r-value for Spearman partial correlations of alcohol markers with CLT adjusting for fibrinogen, HbA1c and BMI to determine how alcohol associates with CLT independent of fibrinogen concentrations as well as HbA1c and BMI
  2. *p < 0.05; **p ≤ 0.01; ***p ≤ 0.001
  3. ALT Alanine transaminase, AST Aspartate aminotransferase, BMI Body mass index, CLT Clot lysis time, CRP High sensitivity C-reactive protein, %CDT Percentage carbohydrate deficient transferrin, GGT Gamma-glutamyltransferase, GGT-CDT 0.8 x ln(GGT) + 1.3 x ln(%CDT), HbA1c Glycosylated haemoglobin A1c, HDL-c High-density lipoprotein cholesterol, LDL-c Low-density lipoprotein cholesterol, n Number of patients, PA Physical activity, r Correlation coefficient; TC Total cholesterol