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Table 4 FGB, FGA, FGG and FXIII gene polymorphisms’ interactions with alcohol intake/markers in relation to haemostasis

From: The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes

Interaction Interaction p-value Genotype r p-value Slope (y = mx + c) CI of slope
QFFQ alcohol intake interactions in relation to maximum absorbance
FGB: rs7439150 < 0.001 AA
AG
GG
−0.24
− 0.02
− 0.08
0.65
0.83
0.003
−0.008
− 0.0004
− 0.0004
−0.004; 0.02
− 0.002; 0.0001
− 0.001; 0
FGB: rs1800790 < 0.001 GG
GA
AA
− 0.08
0.18
a
0.002
0.09
a
− 0.0004
0.004
a
−0.001; 0
0.002; 0.006
a
FGG: rs1049636 0.001 TT
TC
CC
−0.11
0.05
− 0.16
< 0.001
0.31
0.33
− 0.0006
0.0007
− 0.001
−0; 0.001
0; 0.001
− 0.003; 0.001
ALT interactions in relation to total fibrinogen
FGB: rs1800791 0.001 GG
GA
AA
−0.10
0.02
0.93
< 0.001
0.80
0.07
−0.008
0.01
− 0.005
−0.02; − 0.002
0; 0.02
− 0.27; 0.25
FGA: rs6050 0.003 AA
AG
GG
− 0.07
− 0.08
− 0.26
0.08
0.05
0.002
0.006
− 0.01
− 0.03
−0.003; 0.02
− 0.02; − 0.003
− 0.05; − 0.007
FGG: rs2066865 0.004 CC
CT
TT
−0.06
− 0.12
− 0.27
0.12
0.01
0.004
0.005
− 0.01
− 0.03
− 0.003; 0.01
− 0.02; − 0.003
− 0.05; − 0.001
ALT interactions in relation to maximum absorbance
FGB: rs1800791 < 0.001 GG
GA
AA
−0.15
0.01
− 0.65
< 0.001
0.86
0.35
−0.001
0.0009
− 0.005
−0.001; − 0.001
0; 0.002
− 0.04; 0.03
FGG: rs1049636 0.003 TT
TC
CC
− 0.18
− 0.04
− 0.16
< 0.001
0.50
0.33
−0.001
0.0006
− 0.002
−0.002; − 0.001
0; 0.001
− 0.005; 0.001
FXIII: rs6003 < 0.001 AA
AG
GG
−0.04
− 0.16
− 0.14
< 0.001
< 0.001
0.64
0.002
− 0.0008
− 0.001
0; 0.003
− 0.001; 0
− 0.002; − 0.001
AST interactions in relation to maximum absorbance
FGB: rs7439150 < 0.001 AA
AG
GG
−0.13
− 0.16
0.91
< 0.001
0.03
0.01
−0.0003
− 0.0003
0.0
−0.001; 0
− 0.001; 0
− 0.008; 0.04
GGT–CDT interactions in relation to total fibrinogen
FGB: rs2227388 0.001 AA
AG
GG
−0.06
− 0.03
− 0.51
0.03
0.55
0.001
−0.11
− 0.16
− 3.14
−0.23; 0.003
− 0.49; 0.18
− 14.9; 8.63
  1. A Adenine, ALT Alanine transaminase, AST Aspartate aminotransferase, C Cytosine, CDT Carbohydrate deficient transferrin, FGA Fibrinogen alpha chain, FGB Fibrinogen beta chain, FGG Fibrinogen gamma chain, G Guanine, GGT Gamma-glutamyltransferase, GGT-CDT 0.8 x ln(GGT) + 1.3 x ln(%CDT), QFFQ Quantitative food frequency questionnaire, rs Reference sequence, T Thymine
  2. aStratification according to rs1800790 resulted in too few individuals to perform analysis