Table 4 FGB, FGA, FGG and FXIII gene polymorphisms’ interactions with alcohol intake/markers in relation to haemostasis
Interaction | Interaction p-value | Genotype | r | p-value | Slope (y = mx + c) | CI of slope |
|---|---|---|---|---|---|---|
QFFQ alcohol intake interactions in relation to maximum absorbance | ||||||
FGB: rs7439150 | < 0.001 | AA AG GG | −0.24 − 0.02 − 0.08 | 0.65 0.83 0.003 | −0.008 − 0.0004 − 0.0004 | −0.004; 0.02 − 0.002; 0.0001 − 0.001; 0 |
FGB: rs1800790 | < 0.001 | GG GA AA | − 0.08 0.18 a | 0.002 0.09 a | − 0.0004 0.004 a | −0.001; 0 0.002; 0.006 a |
FGG: rs1049636 | 0.001 | TT TC CC | −0.11 0.05 − 0.16 | < 0.001 0.31 0.33 | − 0.0006 0.0007 − 0.001 | −0; 0.001 0; 0.001 − 0.003; 0.001 |
ALT interactions in relation to total fibrinogen | ||||||
FGB: rs1800791 | 0.001 | GG GA AA | −0.10 0.02 0.93 | < 0.001 0.80 0.07 | −0.008 0.01 − 0.005 | −0.02; − 0.002 0; 0.02 − 0.27; 0.25 |
FGA: rs6050 | 0.003 | AA AG GG | − 0.07 − 0.08 − 0.26 | 0.08 0.05 0.002 | 0.006 − 0.01 − 0.03 | −0.003; 0.02 − 0.02; − 0.003 − 0.05; − 0.007 |
FGG: rs2066865 | 0.004 | CC CT TT | −0.06 − 0.12 − 0.27 | 0.12 0.01 0.004 | 0.005 − 0.01 − 0.03 | − 0.003; 0.01 − 0.02; − 0.003 − 0.05; − 0.001 |
ALT interactions in relation to maximum absorbance | ||||||
FGB: rs1800791 | < 0.001 | GG GA AA | −0.15 0.01 − 0.65 | < 0.001 0.86 0.35 | −0.001 0.0009 − 0.005 | −0.001; − 0.001 0; 0.002 − 0.04; 0.03 |
FGG: rs1049636 | 0.003 | TT TC CC | − 0.18 − 0.04 − 0.16 | < 0.001 0.50 0.33 | −0.001 0.0006 − 0.002 | −0.002; − 0.001 0; 0.001 − 0.005; 0.001 |
FXIII: rs6003 | < 0.001 | AA AG GG | −0.04 − 0.16 − 0.14 | < 0.001 < 0.001 0.64 | 0.002 − 0.0008 − 0.001 | 0; 0.003 − 0.001; 0 − 0.002; − 0.001 |
AST interactions in relation to maximum absorbance | ||||||
FGB: rs7439150 | < 0.001 | AA AG GG | −0.13 − 0.16 0.91 | < 0.001 0.03 0.01 | −0.0003 − 0.0003 0.0 | −0.001; 0 − 0.001; 0 − 0.008; 0.04 |
GGT–CDT interactions in relation to total fibrinogen | ||||||
FGB: rs2227388 | 0.001 | AA AG GG | −0.06 − 0.03 − 0.51 | 0.03 0.55 0.001 | −0.11 − 0.16 − 3.14 | −0.23; 0.003 − 0.49; 0.18 − 14.9; 8.63 |