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Table 1 DIC with infectious disease: Patients’ characteristics

From: Analysis of the association between resolution of disseminated intravascular coagulation (DIC) and treatment outcomes in post-marketing surveillance of thrombomodulin alpha for DIC with infectious disease and with hematological malignancy by organ failure

Background factor

Median (range) or n (%)

Sex, n (%)

 Male

848 (42.6)

 Female

1142 (57.4)

Age, years

71 (0–102)

DIC duration before TM-α treatment, days

0 (0–51)

Total dose of TM-α, U/kg

369.2 (45–609.5)

Duration of TM-α

6 (1–27)

Prior DIC treatment, n (%)

 +

762 (38.3)

 -

1228 (61.7)

Prior heparan sulfate and low molecular weight heparin, n (%)

 +

198 (9.9)

 -

1792 (90.1)

Prior serine protease inhibitors, n (%)

 +

550 (27.6)

 -

1440 (72.4)

Prior AT, n (%)

 +

375 (18.8)

 -

1615 (81.2)

Platelets, 104/μL

5.2 (0–126)

PT ratio

1.32 (0.8–19.06)

FDP, μg/mL

29.2 (0.8–3200)

FBG, mg/dL

358.7 (0.1885–1481)

AT, %

55 (7.5–140)

JAAM DIC score

6 (4–8)

SOFA score

10 (1–23)

  1. The plus and minus signs mean with and without treatment, respectively
  2. AT antithrombin, DIC disseminated intravascular coagulation, FBG fibrinogen, FDP fibrin/fibrinogen degradation products, JAAM Japanese Association for Acute Medicine, SOFA sequential organ failure assessment, TM-α recombinant human thrombomodulin