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Table 2 DIC with hematological malignancy: Patients’ characteristics

From: Analysis of the association between resolution of disseminated intravascular coagulation (DIC) and treatment outcomes in post-marketing surveillance of thrombomodulin alpha for DIC with infectious disease and with hematological malignancy by organ failure

Background factor

Median (range) or n (%)

Sex, n (%)

 Male

318 (39.5)

 Female

487 (60.5)

Age, years

63 (0–92)

DIC duration before TM-α treatment, days

0 (−1–31)

Total dose of TM-α, U/kg

380 (100.6–549)

Duration of TM-α

6 (1–28)

Prior DIC treatment, n (%)

 +

197 (24.5)

 -

608 (75.5)

Prior heparan sulfate and low molecular weight heparin, n (%)

 +

101 (12.5)

 -

70.4 (87.5)

Prior serine protease inhibitors, n (%)

 +

92 (11.4)

 -

713 (88.6)

Prior AT, n (%)

 +

42 (5.2)

 -

763 (94.8)

Platelet, 104/μL

3.25 (0.2–51.9)

PT ratio

1.26 (0.76–7.55)

FDP, μg/mL

48.4 (0.8–1760)

FBG, mg/dL

204 (14–966.5)

AT, %

86.1 (10.2–150)

JMHW DIC score

4 (3–9)

  1. The plus and minus signs mean with and without treatment, respectively
  2. AT antithrombin, DIC disseminated intravascular coagulation, FBG fibrinogen, FDP fibrin/fibrinogen degradation products, JMHW Japanese Ministry of Health and Welfare, TM-α recombinant human thrombomodulin