Table 1 Laboratory findings timeline
Laboratory parameter (unit) | At presentation | 3 weeks under HU and LMWH | 10 months after eculizumab initiation | Normal ranges |
|---|---|---|---|---|
Hgb (g/dL) | 1.4 | 17.6 | 10.9 | 14.0–16.5 |
Hct (%) | 44.8 | 55.2 | 36.1 | 38.0–52.0 |
MCV (fL) | 83.5 | 81.2 | 74.3 | 80–96 |
MCH (pg) | 26.4 | 25.9 | 22.4 | 27–31 |
WBC (×109/L) | 4.8 (55% N) | 13.0 (83% N) | 7.0 | 4.5–11.0 |
PLT (×109/L) | 227 | 177 | 241 | 140–440 |
INR | 1.73 | 5.50 | 2.31 | 0.90–1.20 |
APTT (sec) | 40.8 | 62.2 | NA | 29–40 |
Fibrinogen (mg/dL) | 456 | 305 | NA | 180–400 |
D-Dimers (μg/mL) | 3.83 | 3.35 | NA | < 0.5 |
Urea (mg/dL) | 29 | 23 | 29 | 15–43 |
Creatinine (mg/dL) | 0.55 | 0.74 | 0.59 | 0.7–1.2 |
Total bilirubin (mg/dL) | 0.52 | 1.41 | 0.56 | 0.3–1.2 |
Direct bilirubin (mg/dL) | 0.38 | 0.90 | 0.28 | 0–0.3 |
LDH (U/L) | 399 | 280 | 327 | 135–225 |
ALP (U/L) | 940 | 1064 | 468 | 40–129 |
γ-GT (U/L) | 297 | 471 | 125 | 8–61 |
AST (U/L) | 82 | 222 | 22 | 15–40 |
ALT (U/L) | 175 | 290 | 20 | < 41 |
CRP (mg/dL) | 32.1 | 35.60 | 4.41 | 0–5 |
Ferritin (ng/mL) | 160.7 | 95.1 | 20 | 15–150 |
Fe (μg/dL) | 34 | 50 | 8.6 | 37–145 |
Serum Erythropoietin (μIU/mL) | 11.99 | NA | NA | 3.22–31.9 |