Table 1 Clinical symptoms and Laboratory findings of the patient

January 2009

No

HIV (+)

–

August 2014

No

CD4⁺ T count: 346 cells/μL

ART (AZT + 3TC + NVP)

February 2015

No

HIV RNA: undetectable

ART (AZT + 3TC + NVP)

January 2018

Left lower extremity swelling with pain

CD4⁺ T count: 522 cells/μL, HIV RNA: 943 copies/mL

ART (AZT + 3TC + NVP)

February 2018

The maximum circumference of his left thigh was 38 cm and the right thigh was 34 cm. The maximum circumference of his left calf was 27 cm and the right calf was 24 cm. His left lower thigh was inflamed and swollen, accompanied by tenderness and presence of varicose veins.

CD4⁺ T count: 430 cells/μL, HIV RNA:580 copies/mL; Ultrasonography and Vascular CT scan: deep venous thrombosis in left lower extremity; Coagulation function test: PT: 14.0 s (normal, 11–16 s), APTT: 44.3 (normal, 23–40s), INR: 1.16, FIB: 15.1 mg/L (normal, 2-4 mg/L), D-dimer: 6.26 mg/L (normal, 0-1 mg/L); Hematological tests: WBC: 3.28 × 10⁹/L (normal, 3.5–9.5 × 10⁹/L), Hb: 126 g/L (normal, 130-175 g/L), PLT: 66 × 10⁹/L (normal, 125–350 × 10⁹/L; CRP: 32.14 mg/L (normal, 0-5 g/L), PCT: 0.029 ng/ml (normal, 0–0.046 ng/ml), ESR: 41 mm/h;

Autoimmune antibodies: ACA (+), p-ANCA (+), β2-GP1-Ab (+), aCLs IgG: 57 (normal < 22), IgM: 24 (normal < 10)

ART (ABC + 3TC + LPV/r),

LMWH calcium followed by warfarin; methylprednisolone followed by prednisone

August 2018

Left lower extremity revascularized

CD4⁺ T count: 633 cells/μL, HIV RNA: undetectable;

ART (ABC + 3TC + LPV/r)

Coagulation function test: PT: 14.3 s (normal, 11–16 s), APTT: 21.4 (normal, 23–40s), INR: 1.19, FIB: 1.94 mg/L (normal, 2-4 mg/L), D-dimer: 1.12 mg/L (normal, 0-1 mg/L);

Autoimmune antibodies: ACA (−), p-ANCA (−), β2-GP1-Ab (−), aCLs IgG: 19 (normal < 22), IgM: 4 (normal < 10)