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Table 2 Hazard ratio by D-dimer level for all-cause death, cardiac death, and major adverse cardiovascular events (MACE)

From: Prognostic Value of D-dimer in patients with acute coronary syndrome treated by percutaneous coronary intervention: a retrospective cohort study

  Unadjusted
HR (95 % CI)
P-value Model 1
HR (95 % CI)
P-value Model 2
HR (95 % CI)
P-value Model 3
HR (95 % CI)
P-value Model 4
HR (95 % CI)
P-value
All-cause death           
< 420 ng/mL 1 (reference) - 1 (reference) - 1 (reference) - 1 (reference) - 1 (reference) -
420–1150 ng/mL 2.79 (2.04–3.80) < 0.001 1.61 (1.16–2.23) 0.005 1.58 (1.14–2.20) 0.007 1.70 (1.24–2.34) 0.001 1.81 (1.32–2.49) < 0.001
≥ 1150 ng/mL 5.33 (3.83–7.42) < 0.001 2.09 (1.45–3.02) < 0.001 1.98 (1.36–2.89) < 0.001 2.46 (1.73–3.50) < 0.001 3.33 (2.37–4.68) < 0.001
Log (D-dimer) 1.68 (1.52–1.86) < 0.001 1.28 (1.13–1.46) < 0.001 1.26 (1.10–1.44) 0.001 1.36 (1.21–1.54) < 0.001 1.51 (1.46–1.67) < 0.001
Cardiac death           
< 420 ng/mL 1 (reference) - 1 (reference) - 1 (reference) - 1 (reference) - 1 (reference) -
420–1150 ng/mL 2.91 (1.97–4.31) < 0.001 1.17 (1.10–2.52) 0.016 1.67 (1.10–2.54) 0.016 1.67 (1.12–2.50) 0.012 1.82 (1.22–2.72) 0.004
≥ 1150 ng/mL 6.87 (4.61–10.23) < 0.001 2.29 (1.46–3.60) < 0.001 2.15 (1.35–3.42) 0.001 2.76 (1.80–4.24) < 0.001 4.06 (2.69–6.12) < 0.001
Log (D-dimer) 1.77 (1.57-2.00) < 0.001 1.28 (1.09–1.50) 0.003 1.25 (1.06–1.48) 0.008 1.38 (1.19–1.60) < 0.001 1.58 (1.37–1.82) < 0.001
MACE           
< 420 ng/mL 1 (reference) - 1 (reference) - 1 (reference) - 1 (reference) - 1 (reference) -
420–1150 ng/mL 1.86 (1.49–2.32) < 0.001 1.29 (1.02–1.63) 0.031 1.26 (1.00-1.59) 0.052 1.38 (1.10–1.73) 0.005 1.44 (1.15–1.80) 0.002
≥ 1150 ng/mL 2.53 (1.94–3.29) < 0.001 1.44 (1.08–1.92) 0.013 1.37 (1.02–1.83) 0.038 1.60 (1.23–2.11) 0.001 1.89 (1.44–2.47) < 0.001
Log (D-dimer) 1.40 (1.29–1.52) < 0.001 1.15 (1.05–1.27) 0.004 1.14 (1.03–1.26) 0.013 1.21 (1.10–1.33) < 0.001 1.27 (1.16–1.40) < 0.001
  1. Model 1, adjusted for established risk factors (i.e. age, sex, hypertension, diabetes mellitus, peripheral artery diseases, history of CABG or PCI, diagnosis of STEMI, incidence of cardiac arrest, ejection fraction, LDL-C, hsCRP, creatinine, cardiac troponin I, culprit lesion, multivessel disease, pre- and post-procedure TIMI grade flow, door-to-balloon time, stent placements, complete revascularization before discharge, and the use of aspirin, P2Y12 inhibitors and statin); Model 2, adjusted for all collected baseline variables; Model 3, adjusted for the GRACE score; Model 4, adjusted for the TIMI score. CABG = coronary artery bypass grafting, CI = confidence interval, HR = hazard ratio, hsCRP = high-sensitivity C-reactive protein, LDL-C = low-density lipoprotein cholesterol, MACE = major adverse cardiovascular events, PCI = percutaneous coronary intervention, STEMI = ST-segment elevation myocardial infarction, TIMI flow = the Thrombolysis In Myocardial Infarction grade flow, TIMI score = the Thrombolysis In Myocardial Infarction risk score