| Unadjusted HR (95 % CI) | P-value | Model 1 HR (95 % CI) | P-value | Model 2 HR (95 % CI) | P-value | Model 3 HR (95 % CI) | P-value | Model 4 HR (95 % CI) | P-value |
---|---|---|---|---|---|---|---|---|---|---|
All-cause death | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
< 420 ng/mL | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - |
420–1150 ng/mL | 2.79 (2.04–3.80) | < 0.001 | 1.61 (1.16–2.23) | 0.005 | 1.58 (1.14–2.20) | 0.007 | 1.70 (1.24–2.34) | 0.001 | 1.81 (1.32–2.49) | < 0.001 |
≥ 1150 ng/mL | 5.33 (3.83–7.42) | < 0.001 | 2.09 (1.45–3.02) | < 0.001 | 1.98 (1.36–2.89) | < 0.001 | 2.46 (1.73–3.50) | < 0.001 | 3.33 (2.37–4.68) | < 0.001 |
Log (D-dimer) | 1.68 (1.52–1.86) | < 0.001 | 1.28 (1.13–1.46) | < 0.001 | 1.26 (1.10–1.44) | 0.001 | 1.36 (1.21–1.54) | < 0.001 | 1.51 (1.46–1.67) | < 0.001 |
Cardiac death | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
< 420 ng/mL | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - |
420–1150 ng/mL | 2.91 (1.97–4.31) | < 0.001 | 1.17 (1.10–2.52) | 0.016 | 1.67 (1.10–2.54) | 0.016 | 1.67 (1.12–2.50) | 0.012 | 1.82 (1.22–2.72) | 0.004 |
≥ 1150 ng/mL | 6.87 (4.61–10.23) | < 0.001 | 2.29 (1.46–3.60) | < 0.001 | 2.15 (1.35–3.42) | 0.001 | 2.76 (1.80–4.24) | < 0.001 | 4.06 (2.69–6.12) | < 0.001 |
Log (D-dimer) | 1.77 (1.57-2.00) | < 0.001 | 1.28 (1.09–1.50) | 0.003 | 1.25 (1.06–1.48) | 0.008 | 1.38 (1.19–1.60) | < 0.001 | 1.58 (1.37–1.82) | < 0.001 |
MACE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
< 420 ng/mL | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - |
420–1150 ng/mL | 1.86 (1.49–2.32) | < 0.001 | 1.29 (1.02–1.63) | 0.031 | 1.26 (1.00-1.59) | 0.052 | 1.38 (1.10–1.73) | 0.005 | 1.44 (1.15–1.80) | 0.002 |
≥ 1150 ng/mL | 2.53 (1.94–3.29) | < 0.001 | 1.44 (1.08–1.92) | 0.013 | 1.37 (1.02–1.83) | 0.038 | 1.60 (1.23–2.11) | 0.001 | 1.89 (1.44–2.47) | < 0.001 |
Log (D-dimer) | 1.40 (1.29–1.52) | < 0.001 | 1.15 (1.05–1.27) | 0.004 | 1.14 (1.03–1.26) | 0.013 | 1.21 (1.10–1.33) | < 0.001 | 1.27 (1.16–1.40) | < 0.001 |