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Table 3 Additional prognostic value of D-dimer for the primary outcome of all-cause death

From: Prognostic Value of D-dimer in patients with acute coronary syndrome treated by percutaneous coronary intervention: a retrospective cohort study

  Risk factors a All baseline variables GRACE score TIMI score
Original models
C-index 0.842 (0.813–0.871) 0.845 (0.818–0.872) 0.814 (0.780–0.848) 0.776 (0.743–0.809)
Original models + D-dimer (high, median, low)
C-index 0.851 (0.823–0.879) 0.853 (0.826–0.879) 0.826 (0.794–0.859) 0.804 (0.773–0.835)
ΔC-index 0.009 (0.001–0.016) 0.008 (0.001–0.014) 0.012 (0.001–0.024) 0.028 (0.013–0.043)
P difference 0.019 0.021 0.027 < 0.001
Original models + logarithmic D-dimer
C-index 0.849 (0.821–0.877) 0.851 (0.824–0.878) 0.825 (0.793–0.857) 0.800 (0.769–0.831)
ΔC-index 0.006 (0.001–0.012) 0.006 (0.001–0.011) 0.011 (0.002–0.020) 0.024 (0.011–0.037)
P difference 0.020 0.021 0.015 < 0.001
  1. a Risk factors model included age, sex, hypertension, diabetes mellitus, peripheral artery diseases, history of CABG or PCI, diagnosis of STEMI, incidence of cardiac arrest, ejection fraction, LDL-C, hsCRP, creatinine, cardiac troponin I, culprit lesion, multivessel disease, pre- and post-procedure TIMI grade flow, door-to-balloon time, stent placements, complete revascularization before discharge, and the use of aspirin, P2Y12 inhibitors and statin. CABG = coronary artery bypass graft, GRACE score = the Global Registry of Acute Coronary Events risk score, HR = hazard ratio, hsCRP = high-sensitivity C-reactive protein, LDL-C = low-density lipoprotein cholesterol, PCI = percutaneous coronary intervention, STEMI = ST-segment elevation myocardial infarction, TIMI grade flow = the Thrombolysis In Myocardial Infarction grade flow, TIMI score = the Thrombolysis In Myocardial Infarction risk score, ΔC-index = difference of C-index