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Table 3 Additional prognostic value of D-dimer for the primary outcome of all-cause death

From: Prognostic Value of D-dimer in patients with acute coronary syndrome treated by percutaneous coronary intervention: a retrospective cohort study

 

Risk factors a

All baseline variables

GRACE score

TIMI score

Original models

C-index

0.842 (0.813–0.871)

0.845 (0.818–0.872)

0.814 (0.780–0.848)

0.776 (0.743–0.809)

Original models + D-dimer (high, median, low)

C-index

0.851 (0.823–0.879)

0.853 (0.826–0.879)

0.826 (0.794–0.859)

0.804 (0.773–0.835)

ΔC-index

0.009 (0.001–0.016)

0.008 (0.001–0.014)

0.012 (0.001–0.024)

0.028 (0.013–0.043)

P difference

0.019

0.021

0.027

< 0.001

Original models + logarithmic D-dimer

C-index

0.849 (0.821–0.877)

0.851 (0.824–0.878)

0.825 (0.793–0.857)

0.800 (0.769–0.831)

ΔC-index

0.006 (0.001–0.012)

0.006 (0.001–0.011)

0.011 (0.002–0.020)

0.024 (0.011–0.037)

P difference

0.020

0.021

0.015

< 0.001

  1. a Risk factors model included age, sex, hypertension, diabetes mellitus, peripheral artery diseases, history of CABG or PCI, diagnosis of STEMI, incidence of cardiac arrest, ejection fraction, LDL-C, hsCRP, creatinine, cardiac troponin I, culprit lesion, multivessel disease, pre- and post-procedure TIMI grade flow, door-to-balloon time, stent placements, complete revascularization before discharge, and the use of aspirin, P2Y12 inhibitors and statin. CABG = coronary artery bypass graft, GRACE score = the Global Registry of Acute Coronary Events risk score, HR = hazard ratio, hsCRP = high-sensitivity C-reactive protein, LDL-C = low-density lipoprotein cholesterol, PCI = percutaneous coronary intervention, STEMI = ST-segment elevation myocardial infarction, TIMI grade flow = the Thrombolysis In Myocardial Infarction grade flow, TIMI score = the Thrombolysis In Myocardial Infarction risk score, ΔC-index = difference of C-index