Fig. 3

SMS2 deficiency decelerated arteriolar thrombosis. a Representative images of thrombus formation in mesenteric arterioles induced by ferric trichloride injury in WT and SMS2 –/– mice (upper row, WT, lower row, SMS2 –/–). Thrombus size and occlusion time were analyzed as (c) and (d) showed (n = 6, ** P < 0.01). b Tail bleeding time of WT and SMS2 –/– mice (n = 8, ** P < 0.01). e Representative images of thrombus formation in mice with or without D609 (10 mg/kg) treatment. Statistic result of thrombus size was showed in (h) (n = 6, ** P < 0.01). f Arteriovenous shunt thrombosis experiment showed D609 treatment diminished thrombus weight (n = 5, ** P < 0.01). g D609 prolonged tail bleeding time (n = 8, *** P < 0.001)